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ACOT7

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Protein-coding gene in the species Homo sapiens

ACOT7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2QQ2

Identifiers
AliasesACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
External IDsOMIM: 602587; MGI: 1917275; HomoloGene: 15780; GeneCards: ACOT7; OMA:ACOT7 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for ACOT7Genomic location for ACOT7
Band1p36.31Start6,264,269 bp
End6,393,767 bp
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)
Chromosome 4 (mouse)Genomic location for ACOT7Genomic location for ACOT7
Band4|4 E2Start152,262,591 bp
End152,356,312 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • prefrontal cortex

  • right frontal lobe

  • Brodmann area 9

  • pars compacta

  • Pons

  • endothelial cell

  • anterior cingulate cortex

  • middle temporal gyrus

  • spinal ganglia
Top expressed in
  • seminiferous tubule

  • anterior horn of spinal cord

  • medial dorsal nucleus

  • facial motor nucleus

  • dentate gyrus of hippocampal formation granule cell

  • central gray substance of midbrain

  • Medulla Oblongata

  • nucleus of stria terminalis

  • medial vestibular nucleus

  • perirhinal cortex
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11332

70025

Ensembl

ENSG00000097021

ENSMUSG00000028937

UniProt

O00154

Q91V12

RefSeq (mRNA)
NM_181866
NM_007274
NM_181862
NM_181863
NM_181864

NM_181865

NM_001146057
NM_001146058
NM_133348
NM_001369273
NM_001369274

NM_001369275
NM_001369276

RefSeq (protein)

NP_009205
NP_863654
NP_863655
NP_863656

NP_001139529
NP_001139530
NP_579926
NP_001356202
NP_001356203

NP_001356204
NP_001356205

Location (UCSC)Chr 1: 6.26 – 6.39 MbChr 4: 152.26 – 152.36 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000097021Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028937Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.
  6. Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
  7. Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
  8. ^ "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

External links

Further reading


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