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AZIN2
Identifiers
Aliases	AZIN2, ADC, AZI2, ODC-p, ODC1L, ODCp, AZIB1, antizyme inhibitor 2
External IDs	OMIM: 608353; MGI: 2442093; HomoloGene: 62172; GeneCards: AZIN2; OMA:AZIN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.1 Start 33,081,104 bp End 33,123,492 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 128,824,026 bp End 128,856,235 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis C1 segment prefrontal cortex corpus callosum Brodmann area 9 right frontal lobe substantia nigra cingulate gyrus anterior cingulate cortex Top expressed in seminiferous tubule spermatid lumbar spinal ganglion dentate gyrus of hippocampal formation granule cell lens spermatocyte primary visual cortex superior frontal gyrus Rostral migratory stream neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function putrescine transmembrane transporter activity catalytic activity protein binding ornithine decarboxylase activator activity arginine decarboxylase activity ornithine decarboxylase activity Cellular component transport vesicle cytoplasm mitochondrion trans-Golgi network cell projection Golgi apparatus nucleus axon granular vesicle membrane dendrite perinuclear region of cytoplasm cis-Golgi network cytoplasmic vesicle perikaryon endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment cytosol Biological process positive regulation of polyamine transmembrane transport spermatogenesis putrescine transport ornithine metabolic process putrescine biosynthetic process from ornithine trans-Golgi network membrane organization agmatine biosynthetic process positive regulation of catalytic activity polyamine biosynthetic process negative regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113451 242669 Ensembl ENSG00000142920 ENSMUSG00000028789 UniProt Q96A70 Q8BVM4 RefSeq (mRNA) NM_001293562 NM_001301823 NM_001301824 NM_001301825 NM_001301826 NM_052998 NM_001350398 NM_001350399 NM_001350400 NM_001350401 NM_001350402 NM_001376722 NM_001376724 NM_001376725 NM_001376727 NM_001376729 NM_001376730 NM_001376732 NM_001301841 NM_172875 RefSeq (protein) NP_001280491 NP_001288752 NP_001288753 NP_001288754 NP_001288755 NP_443724 NP_001337327 NP_001337328 NP_001337329 NP_001337330 NP_001337331 NP_001363651 NP_001363653 NP_001363654 NP_001363656 NP_001363658 NP_001363659 NP_001363661 NP_001288770 NP_766463 Location (UCSC) Chr 1: 33.08 – 33.12 Mb Chr 4: 128.82 – 128.86 Mb PubMed search
Wikidata
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Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene. In contrast to initial suggestions, Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells

References

1. ^ GRCh38: Ensembl release 89: ENSG00000142920 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028789 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Pitkänen LT, Heiskala M, Andersson LC (October 2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochemical and Biophysical Research Communications. 287 (5): 1051–1057. doi:10.1006/bbrc.2001.5703. PMID 11587527.
6. Zhu MY, Iyo A, Piletz JE, Regunathan S (January 2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochimica et Biophysica Acta (BBA) - General Subjects. 1670 (2): 156–164. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.
7. "Entrez Gene: ADC arginine decarboxylase".
8. Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF). The Biochemical Journal. 409 (1): 187–192. doi:10.1042/BJ20071004. PMID 17900240.
9. López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". The Journal of Biological Chemistry. 281 (41): 30896–30906. doi:10.1074/jbc.M602840200. PMID 16916800.

Further reading

• Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–327. doi:10.1093/dnares/8.6.319. PMID 11853319.
• Coleman CS, Hu G, Pegg AE (May 2004). "Putrescine biosynthesis in mammalian tissues". The Biochemical Journal. 379 (Pt 3): 849–855. doi:10.1042/BJ20040035. PMC 1224126. PMID 14763899.
• Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (March 2005). "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity". Biochemical and Biophysical Research Communications. 328 (1): 206–212. doi:10.1016/j.bbrc.2004.11.172. PMID 15670771.
• López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". The Journal of Biological Chemistry. 281 (41): 30896–30906. doi:10.1074/jbc.M602840200. PMID 16916800.
• Tian H, Liu X, Zhang B, Sun Q, Sun D (June 2007). "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth". Acta Biochimica et Biophysica Sinica. 39 (6): 423–430. doi:10.1111/j.1745-7270.2007.00294.x. PMID 17558447.
• Levin VA, Jochec JL, Shantz LM, Aldape KD (November 2007). "Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy". International Journal of Cancer. 121 (10): 2279–2283. doi:10.1002/ijc.22914. PMID 17582600.
• Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF). The Biochemical Journal. 409 (1): 187–192. doi:10.1042/BJ20071004. PMID 17900240.

External links

• Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser.
• Human AZIN2 genome location and AZIN2 gene details page in the UCSC Genome Browser.

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