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ADH7

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Protein-coding gene in the species Homo sapiens
ADH7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1AGN, 1D1S, 1D1T

Identifiers
AliasesADH7, ADH4, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
External IDsOMIM: 600086; MGI: 87926; HomoloGene: 37333; GeneCards: ADH7; OMA:ADH7 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)
Chromosome 4 (human)Genomic location for ADH7Genomic location for ADH7
Band4q23Start99,412,261 bp
End99,435,510 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for ADH7Genomic location for ADH7
Band3 G3|3 64.13 cMStart137,923,521 bp
End137,939,143 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory zone of nasal mucosa

  • oral cavity

  • nasal epithelium

  • epithelium of nasopharynx

  • mucosa of pharynx

  • mucosa of paranasal sinus

  • gums

  • gingival epithelium

  • testicle

  • palpebral conjunctiva
Top expressed in
  • esophagus

  • superior surface of tongue

  • gastric mucosa

  • mucous cell of stomach

  • epithelium of stomach

  • pyloric antrum

  • transitional epithelium of urinary bladder

  • lip

  • corneal stroma

  • conjunctival fornix
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

131

11529

Ensembl

ENSG00000196344

ENSMUSG00000055301

UniProt

P40394

Q64437

RefSeq (mRNA)

NM_001166504
NM_000673

NM_009626

RefSeq (protein)

NP_000664
NP_001159976

NP_033756

Location (UCSC)Chr 4: 99.41 – 99.44 MbChr 3: 137.92 – 137.94 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene.

Function

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000196344Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000055301Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Satre MA, Zgombić-Knight M, Duester G (Jun 1994). "The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene". The Journal of Biological Chemistry. 269 (22): 15606–12. doi:10.1016/S0021-9258(17)40724-1. PMID 8195208.
  6. ^ "Entrez Gene: ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide".

Further reading

External links

PDB gallery
  • 1agn: X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE 1agn: X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE
  • 1d1s: WILD-TYPE HUMAN SIGMA (CLASS IV) ALCOHOL DEHYDROGENASE 1d1s: WILD-TYPE HUMAN SIGMA (CLASS IV) ALCOHOL DEHYDROGENASE
  • 1d1t: MUTANT OF HUMAN SIGMA ALCOHOL DEHYDROGENASE WITH LEUCINE AT POSITION 141 1d1t: MUTANT OF HUMAN SIGMA ALCOHOL DEHYDROGENASE WITH LEUCINE AT POSITION 141


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