ADK (gene) - Misplaced Pages

Protein-coding gene in the species Homo sapiens

ADK

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1BX4, 2I6A, 2I6B, 4O1L

Identifiers

Aliases

ADK, Adk, 2310026J05Rik, 5033405D03Rik, AI255373, AI987814, Ak, adenosine kinase

External IDs

OMIM: 102750; MGI: 87930; HomoloGene: 4891; GeneCards: ADK; OMA:ADK - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10q22.2\|10q11-q24	Start	74,151,202 bp
Band	10q22.2\|10q11-q24	End	74,709,963 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14\|14 A3	Start	21,102,642 bp
Band	14\|14 A3	End	21,498,637 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cartilage tissue

liver

right lobe of liver

Achilles tendon

oral cavity

gums

mucosa of esophagus

islet of Langerhans

ventricular zone

gingival epithelium

Top expressed in

left lobe of liver

intercostal muscle

deep cerebellar nuclei

myocardium of ventricle

left lung lobe

gallbladder

pontine nuclei

right lung lobe

digastric muscle

soleus muscle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding metal ion binding kinase activity phosphotransferase activity, alcohol group as acceptor ATP binding adenosine kinase activity carbohydrate kinase activity RNA binding
Cellular component	nucleoplasm nucleus cytoplasm cytosol
Biological process	purine ribonucleoside salvage phosphorylation purine-containing compound salvage ribonucleoside monophosphate biosynthetic process AMP salvage dATP biosynthetic process adenosine salvage carbohydrate phosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


132


11534

Ensembl


ENSG00000156110


ENSMUSG00000039197

UniProt


P55263


P55264

RefSeq (mRNA)

NM_001123 NM_001202449 NM_001202450 NM_006721 NM_001369123
NM_001369124


NM_001243041 NM_134079

RefSeq (protein)


NP_001114 NP_001189378 NP_001189379 NP_006712


NP_001229970 NP_598840

Location (UCSC)

Chr 10: 74.15 – 74.71 Mb

Chr 14: 21.1 – 21.5 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

Adenosine kinase is an enzyme that in humans is encoded by the ADK gene.

Function

This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg for activity.

References

^ GRCh38: Ensembl release 89: ENSG00000156110 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000039197 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS (Mar 1996). "Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases". Proc Natl Acad Sci U S A. 93 (3): 1232–7. Bibcode:1996PNAS...93.1232S. doi:10.1073/pnas.93.3.1232. PMC 40062. PMID 8577746.
^ "Entrez Gene: ADK adenosine kinase".

External links

Human ADK genome location and ADK gene details page in the UCSC Genome Browser.

Klobutcher LA, Nichols EA, Kucherlapati RS, Ruddle FH (1976). "Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel". Cytogenet. Cell Genet. 16 (1–5): 171–4. doi:10.1159/000130582. PMID 185014.
Singh B, Hao W, Wu Z, et al. (1996). "Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene". Eur. J. Biochem. 241 (2): 564–71. doi:10.1111/j.1432-1033.1995.tb20220.x_1. PMID 8917457.
McNally T, Helfrich RJ, Cowart M, et al. (1997). "Cloning and expression of the adenosine kinase gene from rat and human tissues". Biochem. Biophys. Res. Commun. 231 (3): 645–50. doi:10.1006/bbrc.1997.6157. PMID 9070863.
Mathews II, Erion MD, Ealick SE (1998). "Structure of human adenosine kinase at 1.5 A resolution". Biochemistry. 37 (45): 15607–20. CiteSeerX 10.1.1.499.8430. doi:10.1021/bi9815445. PMID 9843365.
Van Rompay AR, Johansson M, Karlsson A (1999). "Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein". Eur. J. Biochem. 261 (2): 509–17. doi:10.1046/j.1432-1327.1999.00294.x. PMID 10215863.
Singh B, Lin A, Wu ZC, Gupta RS (2001). "Gene structure for adenosine kinase in Chinese hamster and human: high-frequency mutants of CHO cells involve deletions of several introns and exons". DNA Cell Biol. 20 (1): 53–65. doi:10.1089/10445490150504693. PMID 11242543.
Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics. 2 (6): 642–8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843. S2CID 22665513.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662. S2CID 23060872.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

v t e PDB gallery
1bx4: STRUCTURE OF HUMAN ADENOSINE KINASE AT 1.50 ANGSTROMS 2i6a: Human Adenosine Kinase in Complex With 5'-Deoxy-5-Iodotubercidin 2i6b: Human Adenosine Kinase in Complex with An Acetylinic Inhibitor

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- Gluco- Fructo- Hepatic Galacto- Phosphofructo- 1 Liver Muscle Platelet 2 Riboflavin Shikimate Thymidine ADP-thymidine NAD Glycerol Pantothenate Mevalonate Pyruvate Deoxycytidine PFP Diacylglycerol Phosphoinositide 3 Class I PI 3 Class II PI 3 Sphingosine Glucose-1,6-bisphosphate synthase
2.7.2: COOH acceptor	Phosphoglycerate Aspartate kinase
2.7.3: N acceptor	Creatine
2.7.4: PO₄ acceptor	Phosphomevalonate Adenylate Nucleoside-diphosphate Uridylate Guanylate Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase

DNA-directed DNA polymerase

I/A

Taq

II/B

Pfu

III/C

IV/X

TDT

V/Y

RNA-directed DNA polymerase

Reverse transcriptase

Telomerase

RNA polymerase

Template-directed

RNA-dependent RNA polymerase

Polyadenylation

PAP

PNPase

Phosphorolytic
3' to 5' exoribonuclease

Nucleotidyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase CDP-diacylglycerol—serine O-phosphatidyltransferase CDP-diacylglycerol—inositol 3-phosphatidyltransferase CDP-diacylglycerol—choline O-phosphatidyltransferase
Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases
2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases
2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases
2.7.13: protein-histidine	Protein-histidine pros-kinase Protein-histidine tele-kinase Histidine kinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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Categories:

Function

References

External links

Further reading