Misplaced Pages

AKAP8L

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Protein-coding gene in the species Homo sapiens
AKAP8L
Identifiers
AliasesAKAP8L, HA95, HAP95, NAKAP, NAKAP95, A-kinase anchoring protein 8 like
External IDsOMIM: 609475; MGI: 1860606; HomoloGene: 8658; GeneCards: AKAP8L; OMA:AKAP8L - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)
Chromosome 19 (human)Genomic location for AKAP8LGenomic location for AKAP8L
Band19p13.12Start15,380,050 bp
End15,419,141 bp
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)
Chromosome 17 (mouse)Genomic location for AKAP8LGenomic location for AKAP8L
Band17|17 B1Start32,321,424 bp
End32,350,607 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right uterine tube

  • right lobe of thyroid gland

  • anterior pituitary

  • left lobe of thyroid gland

  • sural nerve

  • right testis

  • left testis

  • right adrenal cortex

  • gastric mucosa
Top expressed in
  • superior frontal gyrus

  • neural layer of retina

  • primary visual cortex

  • entorhinal cortex

  • spermatid

  • cerebellar cortex

  • muscle of thigh

  • perirhinal cortex

  • central gray substance of midbrain

  • spermatocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26993

54194

Ensembl

ENSG00000011243

ENSMUSG00000002625

UniProt

Q9ULX6

Q9R0L7

RefSeq (mRNA)

NM_001291478
NM_014371

NM_017476

RefSeq (protein)

NP_001278407
NP_055186

n/a

Location (UCSC)Chr 19: 15.38 – 15.42 MbChr 17: 32.32 – 32.35 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

A-kinase anchor protein 8-like is a protein that in humans is encoded by the AKAP8L gene.

Interactions

AKAP8L has been shown to interact with:

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000011243Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000002625Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element". The Journal of Biological Chemistry. 275 (28): 21396–21401. doi:10.1074/jbc.M909887199. PMID 10748171.
  6. Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (Jan 2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biology of the Cell. 92 (1): 27–37. doi:10.1016/S0248-4900(00)88761-4. PMID 10761695. S2CID 1354592.
  7. "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like".
  8. Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry. 276 (33): 30694–700. doi:10.1074/jbc.M102809200. PMID 11402034.
  9. Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21 (21): 3703–13. doi:10.1242/jcs.113.21.3703. PMID 11034899.
  10. Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–88. doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639.

External links

Further reading


Stub icon

This article on a gene on human chromosome 19 is a stub. You can help Misplaced Pages by expanding it.

Categories: