Misplaced Pages

ALPK1

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Protein-coding gene in the species Homo sapiens

ALPK1
Identifiers
AliasesALPK1, 8430410J10Rik, LAK, alpha kinase 1, ROSAH
External IDsOMIM: 607347; MGI: 1918731; HomoloGene: 11849; GeneCards: ALPK1; OMA:ALPK1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)
Chromosome 4 (human)Genomic location for ALPK1Genomic location for ALPK1
Band4q25Start112,285,509 bp
End112,442,621 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for ALPK1Genomic location for ALPK1
Band3|3 G2Start127,463,959 bp
End127,574,176 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • tendon of biceps brachii

  • blood

  • pancreatic ductal cell

  • monocyte

  • Achilles tendon

  • gastric mucosa

  • spleen

  • sural nerve

  • skin of abdomen
Top expressed in
  • granulocyte

  • ventricular zone

  • spermatid

  • esophagus

  • embryo

  • genital tubercle

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • superior frontal gyrus

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80216

71481

Ensembl

ENSG00000073331

ENSMUSG00000028028

UniProt

Q96QP1

Q9CXB8

RefSeq (mRNA)

NM_001102406
NM_001253884
NM_025144

NM_027808

RefSeq (protein)

NP_001095876
NP_001240813
NP_079420

n/a

Location (UCSC)Chr 4: 112.29 – 112.44 MbChr 3: 127.46 – 127.57 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene.

Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000073331Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028028Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ryazanov AG, Pavur KS, Dorovkov MV (Mar 1999). "Alpha-kinases: a new class of protein kinases with a novel catalytic domain". Curr Biol. 9 (2): R43–5. Bibcode:1999CBio....9..R43R. doi:10.1016/S0960-9822(99)80006-2. PMID 10021370. S2CID 34505206.
  6. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  7. ^ "Entrez Gene: ALPK1 alpha-kinase 1".

External links

Further reading


Stub icon

This article on a gene on human chromosome 4 is a stub. You can help Misplaced Pages by expanding it.

Categories: