Protein-coding gene in the species Homo sapiens
Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene . Expressed in the gut, it has antibiotic properties.
This gene is a member of the apolipoprotein L gene family . The encoded protein is found in the cytoplasm , where it may affect the movement of lipids or allow the binding of lipids to organelles . In addition, expression of this gene is upregulated by tumor necrosis factor -alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta . Six transcript variants encoding three different isoforms have been found for this gene.
References
^ GRCh38: Ensembl release 89: ENSG00000128284 – Ensembl , May 2017
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics . 74 (1): 71–8. doi :10.1006/geno.2001.6534 . PMID 11374903 .
^ "Entrez Gene: APOL3 apolipoprotein L, 3" .
Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, et al. (2021). "A human apolipoprotein L with detergent-like activity kills intracellular pathogens" . Science . 373 (6552): eabf8113. doi :10.1126/science.abf8113 . PMC 8422858 . PMID 34437126 . S2CID 235915023 .
External links
Further reading
Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (May 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood . 93 (10): 3418–31. doi :10.1182/blood.V93.10.3418.410k23_3418_3431 . PMID 10233894 . Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 . PMID 10591208 . Duchateau PN, Pullinger CR, Cho MH, Eng C, Kane JP (April 2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene" . Journal of Lipid Research . 42 (4): 620–30. doi :10.1016/S0022-2275(20)31171-8 . PMID 11290834 . Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (April 2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue". Genomics . 79 (4): 539–46. doi :10.1006/geno.2002.6729 . PMID 11944986 . Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, et al. (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways" . Oncogene . 22 (21): 3307–18. doi :10.1038/sj.onc.1206406 . PMID 12761501 . Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biology . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802 . Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (March 2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis . 191 (1): 63–72. doi :10.1016/j.atherosclerosis.2006.05.032 . PMID 16806233 . Categories :
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