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ARHGAP9

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Protein-coding gene in humans
ARHGAP9
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2P0D, 2P0H

Identifiers
AliasesARHGAP9, 10C, RGL1, Rho GTPase activating protein 9
External IDsOMIM: 610576; MGI: 2143764; HomoloGene: 13041; GeneCards: ARHGAP9; OMA:ARHGAP9 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)
Chromosome 12 (human)Genomic location for ARHGAP9Genomic location for ARHGAP9
Band12q13.3Start57,472,264 bp
End57,488,814 bp
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)
Chromosome 10 (mouse)Genomic location for ARHGAP9Genomic location for ARHGAP9
Band10|10 D3Start127,157,833 bp
End127,165,812 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • blood

  • spleen

  • appendix

  • monocyte

  • lymph node

  • bone marrow

  • bone marrow cells

  • trabecular bone

  • mucosa of ileum
Top expressed in
  • granulocyte

  • mesenteric lymph nodes

  • blood

  • thymus

  • bone marrow

  • spleen

  • tibiofemoral joint

  • submandibular gland

  • parotid gland

  • stroma of bone marrow
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64333

216445

Ensembl

ENSG00000123329

ENSMUSG00000040345

UniProt

Q9BRR9

n/a

RefSeq (mRNA)
NM_001080156
NM_001080157
NM_032496
NM_001319850
NM_001319851

NM_001319852
NM_001367422
NM_001367423
NM_001367424
NM_001367425
NM_001367426

NM_001285785
NM_146011
NM_001359656
NM_001359657

RefSeq (protein)
NP_001073625
NP_001073626
NP_001306779
NP_001306780
NP_001306781

NP_115885
NP_001354351
NP_001354352
NP_001354353
NP_001354354
NP_001354355
NP_001306779.1

n/a

Location (UCSC)Chr 12: 57.47 – 57.49 MbChr 10: 127.16 – 127.17 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.

Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000123329Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040345Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.
  6. ^ "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

External links

Further reading

PDB gallery
  • 2p0d: ArhGAP9 PH domain in complex with Ins(1,4,5)P3 2p0d: ArhGAP9 PH domain in complex with Ins(1,4,5)P3
  • 2p0f: ArhGAP9 PH domain in complex with Ins(1,3,5)P3 2p0f: ArhGAP9 PH domain in complex with Ins(1,3,5)P3
  • 2p0h: ArhGAP9 PH domain in complex with Ins(1,3,4)P3 2p0h: ArhGAP9 PH domain in complex with Ins(1,3,4)P3


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