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ATF7IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RPQ
Identifiers
Aliases	ATF7IP, AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
External IDs	OMIM: 613644; MGI: 1858965; HomoloGene: 10051; GeneCards: ATF7IP; OMA:ATF7IP - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.1 Start 14,365,632 bp End 14,502,935 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 G1 Start 136,506,167 bp End 136,610,862 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell cardia nipple tendon of biceps brachii renal medulla visceral pleura pylorus ventral tegmental area superior surface of tongue trigeminal ganglion Top expressed in zygote genital tubercle tail of embryo trigeminal ganglion interventricular septum lymph node mesenteric lymph nodes lobe of cerebellum cerebellar vermis secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity protein binding transcription corepressor activity Cellular component nucleus transcription regulator complex nucleoplasm cytosol nuclear body Biological process positive regulation of transcription, DNA-templated DNA methylation regulation of RNA polymerase II transcription preinitiation complex assembly viral process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of protein stability protein stabilization positive regulation of DNA methylation-dependent heterochromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55729 54343 Ensembl ENSG00000171681 ENSMUSG00000030213 UniProt Q6VMQ6 Q7TT18 RefSeq (mRNA) NM_001286514 NM_001286515 NM_018179 NM_181352 NM_019426 RefSeq (protein) NP_001273443 NP_001273444 NP_060649 NP_851997 NP_060649.3 NP_062299 NP_001375123 NP_001375124 NP_001375125 NP_001375126 Location (UCSC) Chr 12: 14.37 – 14.5 Mb Chr 6: 136.51 – 136.61 Mb PubMed search
Wikidata
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Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.

Interactions

ATF7IP has been shown to interact with MBD1. In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000171681 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030213 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
6. De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215. S2CID 22900736.
7. "Entrez Gene: ATF7IP activating transcription factor 7 interacting protein".
8. Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Ohkuma Yoshiaki; Chiba Tsutomu; Saya Hideyuki; Nakao Mitsuyoshi (Apr 2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8). United States: 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. ISSN 0270-7306. PMC 152570. PMID 12665582.
9. Sin, Jun Hyung; Zuckerman, Cassandra; Cortez, Jessica T.; Eckalbar, Walter L.; Erle, David J.; Anderson, Mark S.; Waterfield, Michael R. (2019-09-02). "The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses". The Journal of Experimental Medicine. 216 (9): 2024–2037. doi:10.1084/jem.20182316. ISSN 1540-9538. PMC 6719416. PMID 31217192.
10. Zhao, Zhipeng; Feng, Lu; Peng, Xuerun; Ma, Tingnan; Tong, Rongsheng; Zhong, Lei (2022). "Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response". Frontiers in Pharmacology. 13: 1073713. doi:10.3389/fphar.2022.1073713. ISSN 1663-9812. PMC 9793902. PMID 36582533.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
• Fujita N, Watanabe S, Ichimura T, et al. (2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. PMC 152570. PMID 12665582.
• Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
• Wang H, An W, Cao R, et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Mol. Cell. 12 (2): 475–87. doi:10.1016/j.molcel.2003.08.007. PMID 14536086.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ichimura T, Watanabe S, Sakamoto Y, et al. (2005). "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins". J. Biol. Chem. 280 (14): 13928–35. doi:10.1074/jbc.M413654200. PMID 15691849.
• Chang LK, Chung JY, Hong YR, et al. (2005). "Activation of Sp1-mediated transcription by Rta of Epstein–Barr virus via an interaction with MCAF1". Nucleic Acids Res. 33 (20): 6528–39. doi:10.1093/nar/gki956. PMC 1298921. PMID 16314315.
• Uchimura Y, Ichimura T, Uwada J, et al. (2006). "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation". J. Biol. Chem. 281 (32): 23180–90. doi:10.1074/jbc.M602280200. PMID 16757475.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• Human ATF7IP genome location and ATF7IP gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)

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