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ATOH8
Identifiers
Aliases	ATOH8, HATH6, bHLHa21, atonal bHLH transcription factor 8
External IDs	MGI: 1918343; HomoloGene: 41893; GeneCards: ATOH8; OMA:ATOH8 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p11.2 Start 85,751,344 bp End 85,791,383 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C1 Start 72,183,161 bp End 72,212,561 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right lung tibial nerve popliteal artery tibial arteries thoracic aorta right auricle ascending aorta apex of heart Top expressed in spermatid gastrula seminiferous tubule spermatocyte tail of embryo genital tubercle endothelial cell of lymphatic vessel aortic valve muscle of thigh ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity transcription factor binding E-box binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nuclear speck nucleus nucleoplasm Biological process cell differentiation positive regulation of endothelial cell differentiation regulation of transcription, DNA-templated SMAD protein signal transduction transcription, DNA-templated nervous system development negative regulation of endothelial cell proliferation positive regulation of endothelial cell migration positive regulation of transcription, DNA-templated multicellular organism development tube formation myoblast proliferation formation of primary germ layer negative regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of gene expression negative regulation of gene expression positive regulation of pri-miRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84913 71093 Ensembl ENSG00000168874 ENSMUSG00000037621 UniProt Q96SQ7 Q99NA2 RefSeq (mRNA) NM_032827 NM_153778 RefSeq (protein) NP_116216 NP_722473 Location (UCSC) Chr 2: 85.75 – 85.79 Mb Chr 6: 72.18 – 72.21 Mb PubMed search
Wikidata
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Atonal bHLH transcription factor 8 is a protein that in humans is encoded by the ATOH8 gene. It is hypothesized to play a role endochondral ossification as a regulator of chondrocyte proliferation and differentiation. In addition, it also participates in the chondrogenesis of limb bud mesenchymal progenitor cells.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000168874 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000037621 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Atonal bHLH transcription factor 8". Retrieved 2016-10-19.
6. Schroeder, Nadine; Wuelling, Manuela; Hoffmann, Daniel; Brand-Saberi, Beate; Vortkamp, Andrea (2019-08-26). van Wijnen, Andre (ed.). "Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones". PLOS ONE. 14 (8): e0218230. Bibcode:2019PLoSO..1418230S. doi:10.1371/journal.pone.0218230. ISSN 1932-6203. PMC 6709907. PMID 31449527.
7. Takács, Roland; Vágó, Judit; Póliska, Szilárd; Pushparaj, Peter Natesan; Ducza, László; Kovács, Patrik; Jin, Eun-Jung; Barrett-Jolley, Richard; Zákány, Róza; Matta, Csaba (2023-03-29). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. ISSN 1362-4962. PMC 10164575. PMID 36987858.

Further reading

• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Chen J, Dai F, Balakrishnan-Renuka A, Leese F, Schempp W, Schaller F, Hoffmann MM, Morosan-Puopolo G, Yusuf F, Bisschoff IJ, Chankiewitz V, Xue J, Chen J, Ying K, Brand-Saberi B (2011). "Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor". PLOS ONE. 6 (8): e23005. Bibcode:2011PLoSO...623005C. doi:10.1371/journal.pone.0023005. PMC 3150394. PMID 21857980.
• Güttsches AK, Balakrishnan-Renuka A, Kley RA, Tegenthoff M, Brand-Saberi B, Vorgerd M (2015). "ATOH8: a novel marker in human muscle fiber regeneration". Histochem. Cell Biol. 143 (5): 443–52. doi:10.1007/s00418-014-1299-6. PMID 25514850. S2CID 9753058.

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