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ATP11C
Identifiers
Aliases	ATP11C, ATPIG, ATPIQ, ATPase phospholipid transporting 11C, HACXL
External IDs	OMIM: 300516; MGI: 1859661; HomoloGene: 27862; GeneCards: ATP11C; OMA:ATP11C - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq27.1 Start 139,726,346 bp End 139,945,276 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A6 Start 59,268,650 bp End 59,636,304 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula Achilles tendon testicle gonad tail of epididymis liver parietal pleura superficial temporal artery visceral pleura right lobe of liver Top expressed in liver secondary oocyte ganglionic eminence ventricular zone granulocyte tail of embryo uterus primary oocyte thymus choroid plexus of fourth ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding metal ion binding protein binding hydrolase activity ATP binding magnesium ion binding ATPase-coupled intramembrane lipid transporter activity Cellular component integral component of membrane recycling endosome endoplasmic reticulum membrane membrane plasma membrane lysosomal membrane endoplasmic reticulum trans-Golgi network Biological process pre-B cell differentiation lipid transport positive regulation of B cell differentiation phospholipid transport ion transmembrane transport phospholipid translocation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 286410 320940 Ensembl ENSG00000101974 ENSMUSG00000062949 UniProt Q8NB49 Q9QZW0 RefSeq (mRNA) NM_001010986 NM_173694 NM_001353810 NM_001353811 NM_001353812 NM_001001798 NM_001037863 NM_001359002 RefSeq (protein) NP_001010986 NP_775965 NP_001340739 NP_001340740 NP_001340741 NP_001001798 NP_001032952 NP_001345931 Location (UCSC) Chr X: 139.73 – 139.95 Mb Chr X: 59.27 – 59.64 Mb PubMed search
Wikidata
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ATP11C is an enzyme that in humans is encoded by the ATP11C gene.

Function

ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells, and for the prevention of intrahepatic cholestasis.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000101974 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000062949 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC 3079768. PMID 21423172.
6. Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC 3272780. PMID 21423173.
7. Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. Bibcode:2011PNAS..108.7890S. doi:10.1073/pnas.1104631108. PMC 3093471. PMID 21518881.

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