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ATP6V1E2
Identifiers
Aliases	ATP6V1E2, ATP6E1, ATP6EL2, ATP6V1EL2, VMA4, ATPase H+ transporting V1 subunit E2
External IDs	OMIM: 617385; MGI: 1922165; HomoloGene: 41770; GeneCards: ATP6V1E2; OMA:ATP6V1E2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p21|2p16-p12 Start 46,490,750 bp End 46,542,577 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E4 Start 87,251,537 bp End 87,255,325 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis gonad islet of Langerhans white blood cell monocyte testicle C1 segment muscle of thigh Top expressed in seminiferous tubule spermatid submandibular gland spermatocyte gastrula mucosa of small intestine lumbar spinal ganglion medial ganglionic eminence right ventricle lumbar subsegment of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function P-type proton-exporting transporter activity protein binding proton-transporting ATPase activity, rotational mechanism Cellular component cytosol acrosomal vesicle proton-transporting two-sector ATPase complex, catalytic domain Biological process insulin receptor signaling pathway ion transmembrane transport ion transport transferrin transport regulation of macroautophagy phagosome acidification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90423 74915 Ensembl ENSG00000250565 ENSMUSG00000053375 UniProt Q96A05 Q9D593 RefSeq (mRNA) NM_080653 NM_001318063 NM_001371281 NM_001371282 NM_001371283 NM_029121 RefSeq (protein) NP_001304992 NP_001358210 NP_001358211 NP_001358212 NP_083397 Location (UCSC) Chr 2: 46.49 – 46.54 Mb Chr 17: 87.25 – 87.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

V-type proton ATPase subunit E 2 is an enzyme that in humans is encoded by the ATP6V1E2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000250565 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000053375 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Imai-Senga Y, Sun-Wada GH, Wada Y, Futai M (May 2002). "A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E". Gene. 289 (1–2): 7–12. doi:10.1016/S0378-1119(02)00542-5. PMID 12036578.
6. "Entrez Gene: ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2".

External links

• Human ATP6V1E2 genome location and ATP6V1E2 gene details page in the UCSC Genome Browser.

Further reading

• Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
• Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
• Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263. S2CID 17519696.
• Breton S, Wiederhold T, Marshansky V, et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells". J. Biol. Chem. 275 (24): 18219–24. doi:10.1074/jbc.M909857199. PMID 10748165.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Smith AN, Lovering RC, Futai M, et al. (2003). "Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes". Mol. Cell. 12 (4): 801–3. doi:10.1016/S1097-2765(03)00397-6. PMID 14580332.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.

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