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ATP6V1G3
Identifiers
Aliases	ATP6V1G3, ATP6G3, Vma10, ATPase H+ transporting V1 subunit G3
External IDs	OMIM: 618071; MGI: 2450548; HomoloGene: 13630; GeneCards: ATP6V1G3; OMA:ATP6V1G3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q31.3 Start 198,523,222 bp End 198,540,945 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 138,201,476 bp End 138,217,200 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle human kidney olfactory zone of nasal mucosa muscle of thigh minor salivary glands epithelium of colon mucosa of transverse colon lymph node ganglionic eminence tonsil Top expressed in right kidney human kidney renal cortex skin zone of skin limb muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function ATPase binding P-type proton-exporting transporter activity ATPase-coupled transmembrane transporter activity Cellular component cytosol plasma membrane vacuolar proton-transporting V-type ATPase complex Biological process proton transmembrane transport insulin receptor signaling pathway ion transmembrane transport ion transport transferrin transport phagosome acidification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127124 338375 Ensembl ENSG00000151418 ENSG00000263014 ENSMUSG00000026394 UniProt Q96LB4 Q8BMC1 RefSeq (mRNA) NM_133262 NM_133326 NM_001320218 NM_001376861 NM_001376862 NM_001376863 NM_177397 RefSeq (protein) NP_001307147 NP_573569 NP_579872 NP_001363790 NP_001363791 NP_001363792 NP_796371 Location (UCSC) Chr 1: 198.52 – 198.54 Mb Chr 1: 138.2 – 138.22 Mb PubMed search
Wikidata
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V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.

Function

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.

References

1. ^ ENSG00000263014 GRCh38: Ensembl release 89: ENSG00000151418, ENSG00000263014 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026394 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
6. ^ "Entrez Gene: ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3".

Further reading

• Finbow ME, Harrison MA (Jun 1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". The Biochemical Journal. 324 (Pt 3): 697–712. doi:10.1042/bj3240697. PMC 1218484. PMID 9210392.
• Nelson N, Harvey WR (Apr 1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiological Reviews. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID 10221984. S2CID 1477911.
• Forgac M (May 1999). "Structure and properties of the vacuolar (H+)-ATPases". The Journal of Biological Chemistry. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
• Kane PM (Feb 1999). "Introduction: V-ATPases 1992-1998". Journal of Bioenergetics and Biomembranes. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
• Wieczorek H, Brown D, Grinstein S, Ehrenfeld J, Harvey WR (Aug 1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860. S2CID 23505139.
• Nishi T, Forgac M (Feb 2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nature Reviews Molecular Cell Biology. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
• Kawasaki-Nishi S, Nishi T, Forgac M (Jun 2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Letters. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
• Morel N (Oct 2003). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biology of the Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263.
• Brown D, Lui B, Gluck S, Sabolić I (Oct 1992). "A plasma membrane proton ATPase in specialized cells of rat epididymis". The American Journal of Physiology. 263 (4 Pt 1): C913–6. doi:10.1152/ajpcell.1992.263.4.C913. PMID 1415677.
• Smith AN, Borthwick KJ, Karet FE (Sep 2002). "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis". Gene. 297 (1–2): 169–77. doi:10.1016/S0378-1119(02)00884-3. PMID 12384298.

External links

• Human ATP6V1G3 genome location and ATP6V1G3 gene details page in the UCSC Genome Browser.

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