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In enzymology, an ATP diphosphatase (EC 3.6.1.8) is an enzyme that catalyzes the chemical reaction

ATP + H₂O ${\displaystyle \rightleftharpoons }$ AMP + diphosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are AMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is ATP diphosphohydrolase (diphosphate-forming). Other names in common use include ATPase, ATP pyrophosphatase, adenosine triphosphate pyrophosphatase, and ATP diphosphohydrolase . This enzyme participates in purine metabolism and pyrimidine metabolism.

References

• HEPPEL LA, HILMOE RJ (1953). "Mechanism of enzymatic hydrolysis of adenosinetriphosphate". J. Biol. Chem. 202 (1): 217–26. PMID 13061448.
• JOHNSON M, KAYE MA, HEMS R, KREBS HA (1953). "Enzymic hydrolysis of adenosine phosphates by cobra venom". Biochem. J. 54 (4): 625–9. PMC 1269107. PMID 13058963.

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