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TNFSF13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZCH
Identifiers
Aliases	TNFSF13, APRIL, CD256, TALL-2, TALL2, TRDL-1, ZTNF2, UNQ383/PRO715, TNLG7B, tumor necrosis factor superfamily member 13, TNF superfamily member 13
External IDs	OMIM: 604472; MGI: 1916833; HomoloGene: 56971; GeneCards: TNFSF13; OMA:TNFSF13 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 7,558,292 bp End 7,561,608 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B3 Start 69,573,672 bp End 69,576,610 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte duodenum mucosa of transverse colon gallbladder blood right lung upper lobe of left lung human kidney rectum Top expressed in layer of retina neural layer of retina colon ileum jejunum duodenum granulocyte lung esophagus bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding tumor necrosis factor receptor binding cytokine activity Cellular component cytosol membrane nucleoplasm cytoplasm extracellular exosome extracellular region extracellular space Biological process tumor necrosis factor-mediated signaling pathway regulation of mRNA stability positive regulation of cell population proliferation immune system process signal transduction positive regulation of isotype switching to IgA isotypes immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8741 69583 Ensembl ENSG00000161955 ENSMUSG00000089669 UniProt O75888 Q9D777 RefSeq (mRNA) NM_001198622 NM_001198623 NM_001198624 NM_003808 NM_172087 NM_172088 NM_001159505 NM_023517 RefSeq (protein) NP_001185551 NP_001185552 NP_001185553 NP_003799 NP_742084 NP_742085 NP_001152977 NP_076006 Location (UCSC) Chr 17: 7.56 – 7.56 Mb Chr 11: 69.57 – 69.58 Mb PubMed search
Wikidata
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A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. It is encoded by the TNFSF13 gene.

Nomenclature

In the cluster of differentiation terminology, APRIL is designated CD256.

Function

The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in APRIL have normal immune system development. However, APRIL-deficient mice have also been reported to possess a reduced ability to support plasma cell survival. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Interactions

TNFSF13 has been shown to interact with TNFRSF13B and B-cell activating factor.

Clinical significance

APRIL is being explored as a target for autoimmune diseases and B cell malignancies. At least one anti-APRIL monoclonal antibody has been announced to enter phase I clinical trials for multiple myeloma.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000161955 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000089669 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL, et al. (September 1998). "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth". The Journal of Experimental Medicine. 188 (6): 1185–1190. doi:10.1084/jem.188.6.1185. PMC 2212534. PMID 9743536.
6. ^ "Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13". National Library of Medicine. 10 October 2023. Retrieved 13 October 2023.
7. Varfolomeev E, Kischkel F, Martin F, Seshasayee D, Wang H, Lawrence D, et al. (February 2004). "APRIL-deficient mice have normal immune system development". Molecular and Cellular Biology. 24 (3): 997–1006. doi:10.1128/MCB.24.3.997-1006.2004. PMC 321448. PMID 14729948.
8. Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, et al. (March 2008). "APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells". Blood. 111 (5): 2755–2764. doi:10.1182/blood-2007-09-110858. PMID 18180376.
9. Roth W, Wagenknecht B, Klumpp A, Naumann U, Hahne M, Tschopp J, et al. (April 2001). "APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis". Cell Death and Differentiation. 8 (4): 403–410. doi:10.1038/sj.cdd.4400827. PMID 11550092.
10. Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, et al. (November 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry. 275 (45): 35478–35485. doi:10.1074/jbc.M005224200. PMID 10956646.
11. Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, et al. (October 2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". Journal of Immunology. 169 (8): 4314–4321. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
12. Ryan MC, Grewal IS (2009-01-01). "Targeting of BAFF and APRIL for Autoimmunity and Oncology". In Grewal IS (ed.). Therapeutic Targets of the TNF Superfamily. Advances in Experimental Medicine and Biology. Vol. 647. New York: Springer. pp. 52–63. doi:10.1007/978-0-387-89520-8_4. ISBN 978-0-387-89519-2. PMID 19760066.
13. "Development of a first in class APRIL fully blocking antibody BION-1301 for the treatment of multiple myeloma". AACR 2017 Proceedings. April 2017.

Further reading

• Bossen C, Schneider P (October 2006). "BAFF, APRIL and their receptors: structure, function and signaling". Seminars in Immunology. 18 (5): 263–275. doi:10.1016/j.smim.2006.04.006. PMID 16914324.
• Tangye SG, Bryant VL, Cuss AK, Good KL (October 2006). "BAFF, APRIL and human B cell disorders". Seminars in Immunology. 18 (5): 305–317. doi:10.1016/j.smim.2006.04.004. PMID 16916610.
• Treml LS, Crowley JE, Cancro MP (October 2006). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Seminars in Immunology. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
• Mackay F, Leung H (October 2006). "The role of the BAFF/APRIL system on T cell function". Seminars in Immunology. 18 (5): 284–289. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Shu HB, Hu WH, Johnson H (May 1999). "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens". Journal of Leukocyte Biology. 65 (5): 680–683. doi:10.1002/jlb.65.5.680. PMID 10331498. S2CID 1498303.
• Cousin P, Billotte J, Chaubert P, Shaw P (January 2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics. 63 (1): 60–68. doi:10.1006/geno.1999.6062. PMID 10662545.
• Kelly K, Manos E, Jensen G, Nadauld L, Jones DA (February 2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Research. 60 (4): 1021–1027. PMID 10706119.
• Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, et al. (November 2000). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". The Journal of Biological Chemistry. 275 (45): 35478–35485. doi:10.1074/jbc.M005224200. PMID 10956646.
• Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, et al. (September 2000). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nature Immunology. 1 (3): 252–256. doi:10.1038/79802. PMID 10973284. S2CID 6799584.
• López-Fraga M, Fernández R, Albar JP, Hahne M (October 2001). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Reports. 2 (10): 945–951. doi:10.1093/embo-reports/kve198. PMC 1084076. PMID 11571266.
• Stein JV, López-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodríguez D, Gómez-Caro R, et al. (June 2002). "APRIL modulates B and T cell immunity". The Journal of Clinical Investigation. 109 (12): 1587–1598. doi:10.1172/JCI15034. PMC 151011. PMID 12070306.
• Litinskiy MB, Nardelli B, Hilbert DM, He B, Schaffer A, Casali P, et al. (September 2002). "DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL". Nature Immunology. 3 (9): 822–829. doi:10.1038/ni829. PMC 4621779. PMID 12154359.
• Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, et al. (October 2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". Journal of Immunology. 169 (8): 4314–4321. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
• Pradet-Balade B, Medema JP, López-Fraga M, Lozano JC, Kolfschoten GM, Picard A, et al. (November 2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein". The EMBO Journal. 21 (21): 5711–5720. doi:10.1093/emboj/cdf565. PMC 131062. PMID 12411489.

External links

• TNFSF13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human TNFSF13 genome location and TNFSF13 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

• Genes on human chromosome 17
• Clusters of differentiation