Ababio is a surname. Notable people with the surname include:
- Alexander Ransford Ababio (born 1927), Ghanaian politician
- Eddie Ababio (born 1988), Ghanaian-American soccer player
- Joyce Ababio (born 1988), Ghanaian fashion designer
- Odeneho Gyapong Ababio II, Ghanaian traditional ruler
- Yaw Ntow Ababio (born 1959), Ghanaian politician
See also
- Gottlieb Ababio Adom (1904–1979), Ghanaian educator, journalist, editor and Presbyterian minister
- Grace Amponsah-Ababio (born 1941), Ghanaian dentist and diplomat
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