| Acetoacetate—CoA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.2.1.16 | ||||||||
| CAS no. | 39394-62-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an acetoacetate—CoA ligase (EC 6.2.1.16) is an enzyme that catalyzes the chemical reaction
- ATP + acetoacetate + CoA AMP + diphosphate + acetoacetyl-CoA
AMP + diphosphate + acetoacetyl-CoAThe 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetoacetate:CoA ligase (AMP-forming). This enzyme is also called acetoacetyl-CoA synthetase. This enzyme participates in butanoate metabolism.
References
- Fukui T, Ito M, Tomita K (1982). "Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M". Eur. J. Biochem. 127 (2): 423–8. doi:10.1111/j.1432-1033.1982.tb06889.x. PMID 7140777.
| Enzymes: CO CS and CN ligases (EC 6.1-6.3) | |
|---|---|
| 6.1: Carbon-Oxygen | |
| 6.2: Carbon-Sulfur | |
| 6.3: Carbon-Nitrogen | |
| Enzymes | |
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| Activity | |
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| Classification | |
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