acetoacetyl-CoA reductase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Acetoacetyl-CoA reductase tetramer, Cupriavidus necator | |||||||||
Identifiers | |||||||||
EC no. | 1.1.1.36 | ||||||||
CAS no. | 9028-41-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, an acetoacetyl-CoA reductase (EC 1.1.1.36) is an enzyme that catalyzes the chemical reaction
- (R)-3-hydroxyacyl-CoA + NADP 3-oxoacyl-CoA + NADPH + H
Thus, the two substrates of this enzyme are (R)-3-hydroxyacyl-CoA and NADP, whereas its 3 products are 3-oxoacyl-CoA, NADPH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-3-hydroxyacyl-CoA:NADP oxidoreductase. Other names in common use include acetoacetyl coenzyme A reductase, hydroxyacyl coenzyme-A dehydrogenase, NADP-linked acetoacetyl CoA reductase, NADPH:acetoacetyl-CoA reductase, D(−)-beta-hydroxybutyryl CoA-NADP oxidoreductase, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase, beta-ketoacyl-CoA reductase, D-3-hydroxyacyl-CoA reductase, and (R)-3-hydroxyacyl-CoA dehydrogenase. This enzyme participates in butanoate metabolism.
References
- Wakil S, Bressler R (March 1962). "Studies on the mechanism of fatty acid synthesis. X. Reduced triphosphopyridine nucleotide-acetoacetyl coenzyme A reductase". The Journal of Biological Chemistry. 237 (3): 687–93. doi:10.1016/S0021-9258(18)60356-4. PMID 14004466.
Enzymes | |
---|---|
Activity | |
Regulation | |
Classification | |
Kinetics | |
Types |
|
This EC 1.1.1 enzyme-related article is a stub. You can help Misplaced Pages by expanding it. |