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Acylglycerone-phosphate reductase

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Class of enzymes
acylglycerone-phosphate reductase
Identifiers
EC no.1.1.1.101
CAS no.37250-35-4
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In enzymology, an acylglycerone-phosphate reductase (EC 1.1.1.101) is an enzyme that catalyzes the chemical reaction

1-palmitoylglycerol 3-phosphate + NADP {\displaystyle \rightleftharpoons } palmitoylglycerone phosphate + NADPH + H

Thus, the two substrates of this enzyme are 1-palmitoylglycerol 3-phosphate and NADP, whereas its 3 products are palmitoylglycerone phosphate, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 1-palmitoylglycerol-3-phosphate:NADP oxidoreductase. Other names in common use include palmitoyldihydroxyacetone-phosphate reductase, palmitoyl dihydroxyacetone phosphate reductase, palmitoyl-dihydroxyacetone-phosphate reductase, acyldihydroxyacetone phosphate reductase, and palmitoyl dihydroxyacetone phosphate reductase. This enzyme participates in glycerophospholipid and ether lipid metabolism.

References

  • LaBelle EF, Hajra AK (September 1972). "Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides". The Journal of Biological Chemistry. 247 (18): 5825–34. PMID 4403490.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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