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Adibendan

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Adibendan
Names
Preferred IUPAC name 7,7-Dimethyl-2-(pyridin-4-yl)-5,7-dihydroimidazoindol-6(1H)-one
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C16H14N4O/c1-16(2)10-7-12-13(8-11(10)20-15(16)21)19-14(18-12)9-3-5-17-6-4-9/h3-8H,1-2H3,(H,18,19)(H,20,21)Key: TVLQBBHUNDMTEC-UHFFFAOYSA-N
  • InChI=1/C16H14N4O/c1-16(2)10-7-12-13(8-11(10)20-15(16)21)19-14(18-12)9-3-5-17-6-4-9/h3-8H,1-2H3,(H,18,19)(H,20,21)Key: TVLQBBHUNDMTEC-UHFFFAOYAG
SMILES
  • CC1(C2=CC3=C(C=C2NC1=O)NC(=N3)C4=CC=NC=C4)C
Properties
Chemical formula C16H14N4O
Molar mass 278.315 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Adibendan is an inhibitor of phosphodiesterase 3. It has been tested in dogs for its effects on heart output and dilation of blood vessels.

References

  1. Dorszewski, A; Müller-Beckmann, B; Kling, L; Sponer, G (1990). "Haemodynamic profile of an inhibitor of phosphodiesterase III, adibendan (BM 14.478): Comparison with nitroprusside and dobutamine in conscious dogs". British Journal of Pharmacology. 101 (3): 686–90. doi:10.1111/j.1476-5381.1990.tb14141.x. PMC 1917742. PMID 2076485.


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