Agatha may refer to:
- Agatha (given name), a feminine given name
- Agatha, Alberta, a locality in Canada
- List of storms named Agatha, tropical storms and hurricanes
- Operation Agatha, a 1946 British police and military operation in Mandatory Palestine
- Agatha (genus), a genus of gastropods
- Agatha (film), a 1979 film about Agatha Christie
- Agatha All Along (miniseries), a 2024 television series based on the Marvel Comics character Agatha Harkness
- Agatha Award, for mystery and crime writers
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