Agosti is an Italian surname. Notable people with the surname include:
- Antonio Pacheco D'Agosti (born 1976), Uruguayan footballer
- Carlos Agostí (1922–2002), Spanish-born Mexican film actor
- Deborah Agosti (born c. 1952), American judge from Nevada
- Ghigo Agosti (born 1936), Italian singer, musician and composer
- Guido Agosti (1901–1989), Italian pianist and piano teacher
- Livia Leu Agosti (born 1961), Swiss diplomat
- Lucilla Agosti (born 1978), Italian radio and television presenter and actress
- Mario Agosti (1904-1992), Italian athlete
- Maristella Agosti, Italian information engineer
- Orlando Ramón Agosti (1924–1997), Argentine air force general
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