Agostinelli is a surname. Notable people with the name include:
- Alejandro Agostinelli, Argentine journalist
- Alessandro Agostinelli (born 1965), Italian writer and journalist
- Andrea Agostinelli (born 1957), Italian footballer and coach
- Bruno Agostinelli (1987–2016), Canadian tennis player
- Cataldo Agostinelli (1894–1988), Italian mathematician
- Donatella Agostinelli (born 1974), Italian politician
- Franco Agostinelli (born 1944), Italian prelate
- Massimo Agostinelli (born 1987), Swiss based Italian American artist
- Nathan G. Agostinelli (born 1930), American politician
- Robert Agostinelli, American billionaire
- Sal Agostinelli (born 1961), American baseball player, coach, and scout
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