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Aldos-2-ulose dehydratase (EC 4.2.1.110, pyranosone dehydratase, AUDH, 1,5-anhydro-D-fructose dehydratase (microthecin-forming)) is an enzyme with systematic name 1,5-anhydro-D-fructose hydro-lyase (microthecin-forming). This enzyme catalyses the following chemical reaction

1,5-anhydro-D-fructose ${\displaystyle \rightleftharpoons }$ 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H₂O (overall reaction)

(1a) 1,5-anhydro-D-fructose ${\displaystyle \rightleftharpoons }$ 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H₂O

(1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose ${\displaystyle \rightleftharpoons }$ 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one

This enzyme catalyses two of the steps in the anhydrofructose pathway.

References

1. Yu S, Fiskesund R (September 2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochimica et Biophysica Acta (BBA) - General Subjects. 1760 (9): 1314–22. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618.
2. Yu S (May 2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochimica et Biophysica Acta. 1723 (1–3): 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041.
3. Broberg, A.; Kenne, L.; Pedersén, M. (1996). "Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose". Phytochemistry. 41 (1): 151–154. Bibcode:1996PChem..41..151B. doi:10.1016/0031-9422(95)00587-0.
4. Gabriel J, Volc J, Sedmera P, Daniel G, Kubátová E (1993). "Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products". Archives of Microbiology. 160 (1): 27–34. doi:10.1007/BF00258142. PMID 8352649. S2CID 5987101.
5. Yu S, Refdahl C, Lundt I (May 2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochimica et Biophysica Acta. 1672 (2): 120–9. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094.

External links

• Aldos-2-ulose+dehydratase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 4.2.1