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In enzymology, an aldose 1-dehydrogenase (EC 1.1.1.121) is an enzyme that catalyzes the chemical reaction

D-aldose + NAD ${\displaystyle \rightleftharpoons }$ D-aldonolactone + NADH + H

Thus, the two substrates of this enzyme are D-aldose and NAD, whereas its 3 products are D-aldonolactone, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is D-aldose:NAD 1-oxidoreductase. Other names in common use include aldose dehydrogenase, and dehydrogenase, D-aldohexose.

References

• Cline AL, Hu AS (1965). "The isolation of three sugar dehydrogenases from a psuedomonad [sic]". J. Biol. Chem. 240 (11): 4488–92. PMID 5845847.
• Cline AL, Hu AS (1965). "Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4493–7. PMID 5845848.
• Cline AL, Hu AS (1965). "Some physical properties of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4498–502. PMID 5845849.

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