Alfred Müller or Alfred Mueller may refer to:
- Alfred Müller (entrepreneur) (1888–1945), Croatian entrepreneur
- Alfred Müller-Armack (1901–1978), German economist and politician
- Alfred Müller (runner) (1905–1959), German Olympic middle-distance runner
- Alfred Müller (general) (1915–1997), German Wehrmacht general
- Alfred Müller (swimmer) (born 1948), German Olympic swimmer
- Alfred Mueller (born 1939), American theoretical physicist
- Alfred Müller-Felsenburg, honored by the Alfred-Müller-Felsenburg-Preis literary prize in Germany
- Alfred Muller (1940-2020), former (1993-1997) French deputy
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