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Alzheimer's Disease Cooperative Study

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The Alzheimer's Disease Cooperative Study (ADCS) was founded at University of California San Diego in 1991 and coordinates clinical trials of candidate treatments for Alzheimer's disease.

It is funded by the National Institutes of Health as well as companies that develop drugs. The center has coordinated important clinical trials on AD drugs like solanezumab.

History

As of 2008, 75 research sites in the United States and Canada were part of the consortium. Leon Thal served as director until February 2007, when he died; Paul Aisen was recruited to succeed him.

In 2006, the NIH awarded $52 million to ADCS to fund 6 years of further clinical trials.

In 2013 Eli Lilly committed to spending $76.6 million on clinical trials through the center.

Aisen left UCSD in 2015 because he was unhappy with the level of support that UCSD was providing him and due to USC's offer. UCSD and USC ended up in litigation over control of the ADCS and its research data, which at that time involved six ongoing clinical trials and data collected on thousands of clinical trial subjects. Part of the dispute arose because Aisen's lab had uploaded the data from the ADCS onto Amazon Cloud servers and would not give the passwords to UCSD officials. Some aspects of data management were temporarily settled in 2016; as of 2017 the litigation was ongoing. The lawsuit was settled in 2019.

References

  1. ^ Garde, Damian (August 5, 2015). "Judge orders a halt to Alzheimer's spat as Eli Lilly chooses sides in dispute". FierceBiotech.
  2. "Paul Aisen, MD, Joins Faculty of UCSD and is Appointed New Director of the Alzheimer's Disease Cooperative Study". Journal of Investigative Medicine. 56 (1): 3. January 2008. doi:10.1097/01.JIM.0000308082.54350.ba.
  3. Terry, Mark (July 22, 2015). "Eli Lilly Increases San Diego R&D Space by 140%, Staff by 70%". BioSpace via PharmaLive.
  4. Fikes, Bradley J. (5 July 2015). "UC San Diego sues USC and scientist, alleging conspiracy to take funding, data". Los Angeles Times.
  5. Check Hayden, Erika (16 July 2015). "Alzheimer's data lawsuit is sign of growing tensions". Nature. 523 (7560): 265. doi:10.1038/nature.2015.17932.
  6. Basken, Paul (23 July 2015). "Grant Dispute Throws an Unwritten Rule of Academic Poaching Out the Window". The Chronicle of Higher Education.
  7. Fikes, Bradley J. (2 August 2015). "Next steps for scientist in eye of UCSD-USC Alzheimer's spat". San Diego Tribune.
  8. Wang, Shirley S.; Loftus, Peter (14 October 2015). "Alzheimer's Research Effort Is Ensnared in Legal Dispute". Wall Street Journal.
  9. Potter, Matt (January 11, 2016). "Deal gives UCSD "read only" rights to Alzheimer's data". San Diego Reader.
  10. "Case 3:15-cv-01766: The Regents of the University of California v. Aisen et al (3:15-cv-01766), California Southern District Court". PacerMonitor. Retrieved 15 June 2017.
  11. "Case 8:17-cv-00721: The Regents of the University of California v. Aisen et al (8:17-cv-00721), Maryland District Court". PacerMonitor. Retrieved 15 June 2017.
  12. "USC pays UCSD $50M, and gives the school an apology, for raiding its Alzheimer's program". San Diego Union-Tribune. 2019-07-04. Retrieved 2022-09-14.
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