Amsalem is a surname of Maghrebi Jewish origin. Notable people with the surname include:
- Bernard Amsalem (born 1951), French organizer of athletics
- David Amsalem (born 1971), Israeli footballer
- Dudu Amsalem (born 1960), Israeli politician
- Haim Amsalem (born 1959), Israeli politician
- Reymond Amsalem (born 1978), Israeli actress
- Shimon Amsalem (born 1966), Israeli basketball player
- Nissim Eliad (born Nissim Amsalem 1919), Israeli politician and lawyer
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