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The results of an autopsy on a deceased newcomer to the beach bring a surprising twist to the person's death.

Mark serves jury duty on a case in which a notorious hit man is found innocent - only to be killed by a bomb that the prosecutor planted for revenge. Mark's effort to prove the prosecutor did uncovers surprising details about her life and the hitman's.

A man falsely convicted of killing his wife takes Mark hostage in order to prove his innocence. (A train transporting prisoners derails, sending him to the hospital--partly inspired by The Fugitive (1993 film).)

Sloan becomes convinced that George Karn (Jeff Allin) is innocent, so he sets out to find the man who killed Karn's wife. But a hardened police officer constantly impedes his efforts.

Steve becomes attracted to a female reporter who murders cops.

Dr Jesse gets involved in a large conspiracy when he sees an alleged heart-attack victim, while a wealthy benefactor takes a shine to Briggs.

Someone is murdering homeless people and harvesting their organs for transplants, so Mark poses as a vagrant to flush them out.

Sloan faces double trouble while investigating the murders of an old friend (Robert Vaughn) and his young wife (Ruth McGinnis), the prime suspect being the friend's sister-in-law (also McGinnis), his wife's identical twin.

Dr John Foster, a pioneering New York surgeon, arrives at Community General Hospital to perform an abdominal aortic procedure on a wealthy patient. The night before the surgery, Dr Mark is concerned to note that Dr John is drinking rather heavily. Dr John turns up for the surgery in an intoxicated state and is ordered out of the OR by Dr Claire Hartman who then performs the surgery. He then goes on a bender and later arrives at Dr Claire’s apartment and has a furious row with her.
Dr Claire is found dead the next morning.
Mark diagnoses that John is a full-blown alcoholic and furthermore John has no memory of going to Dr Claire’s apartment – or much of anything else, from the night before. But might Dr Claire’s fast and loose private life hold the real key to her murder?
Look out for the bartender who Jesse speaks to at the Whirlwind Club. He is played by Kevin McNally, Dick Van Dyke’s real-life son in law and, in later seasons, the recurring character of Will Sanders a Fire Department Paramedic, who frequently wheels patients into the CGH Reception area while summarising the patient’s injuries for the medical staff.

A picture taken by a paparazzo provides a clue in a kidnapping and murder case, while Amanda goes into labor.

A Psychotherapist murders a downsizing expert who threatened Mark Sloan's job, then attempts to blackmail the doctor into returning the favor.

A psychic from an infomercial claims she saw a future murder being committed.

Call girls and the co-author of their racy book, ‘Munchies, Snacks and Spreads’, are being threatened with murder, while Dr Amanda discovers she was never legally married.

Sloan suspects a TV homemaker (Vicki Lawrence) murdered a perverted radio host (Morton Downey Jr.) who got her pregnant.

The remains of Sloan's friend are found in a dead shark, which is made all the more suspicious when it's discovered the victim had three wives.
Curio: In this episode, Dr Amanda is very clearly pregnant. So, sequentially, the events of this episode must have taken place prior to those in episode 13 (‘35 Millimetre Murder’) when Dr Amanda gave birth – with Dr Jesse’s assistance.