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Anchoring fibrils (composed largely of type VII collagen) extend from the basal lamina of epithelial cells and attach to the lamina reticularis (also known as the reticular lamina) by wrapping around the reticular fiber (collagen III) bundles. The basal lamina and lamina reticularis together make up the basement membrane. Anchoring fibrils are essential to the functional integrity of the dermoepidermal junction.

Epidermolysis bullosa dystrophica

Epidermolysis bullosa dystrophica, also known as Dystrophic EB (DEB) is a chronic skin condition caused when anchoring fibrils are abnormal, diminished, or absent. This causes a weak dermoepidermal junction, where the epidermis easily separates from the dermis causing much pain. This condition is caused by a mutation of COL7A1, the gene that codes for a type of collagen 7.

See also

• Epidermis (skin)
• Dermis
• Lamina propria
• Connective tissue

References

1. Regauer, S.; Seiler, GR; Barrandon, Y; Easley, KW; Compton, CC (1990). "Epithelial origin of cutaneous anchoring fibrils". The Journal of Cell Biology. 111 (5): 2109–15. doi:10.1083/jcb.111.5.2109. PMC 2116344. PMID 2229187.
2. Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter; Marshall, John F.; McGrath, John A.; Mellerio, Jemima E. (2020-09-24). "Epidermolysis bullosa". Nature Reviews Disease Primers. 6 (1): 78. doi:10.1038/s41572-020-0210-0. ISSN 2056-676X. PMID 32973163. S2CID 221861310.
3. Burgeson, Robert E. (1993). "Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa". Journal of Investigative Dermatology. 101 (3): 252–5. doi:10.1111/1523-1747.ep12365129. PMID 8370960.
4. Bruckner-Tuderman, Leena; Höpfner, Bianca; Hammami-Hauasli, Nadja (1999). "Biology of anchoring fibrils: Lessons from dystrophic epidermolysis bullosa". Matrix Biology. 18 (1): 43–54. doi:10.1016/S0945-053X(98)00007-9. PMID 10367730.

• Keene, Douglas R.; Sakai, Lynn Y.; Lunstrum, Gregory P.; Morris, Nicholas P.; Burgeson, Robert E. (1987). "Type VII collagen forms an extended network of anchoring fibrils". The Journal of Cell Biology. 104 (3): 611–21. doi:10.1083/jcb.104.3.611. PMC 2114566. PMID 3818794.
• McGrath, John A.; Ishida-Yamamoto, Akemi; O'Grady, Anthony; Leigh, Irene M.; Eady, Robin A. J. (1993). "Structural Variations in Anchoring Fibrils in Dystrophic Epidermolysis Bullosa: Correlation with Type VII Collagen Expression". Journal of Investigative Dermatology. 100 (4): 366–72. doi:10.1111/1523-1747.ep12471830. PMID 8454899.

External links

• "Skin Basement Membrane". The Doctor's Doctor. April 10, 2006.

• Structural proteins