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Andrew P. Carter

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British structural biologist

Andrew P Carter
NationalityBritish
Alma mater
AwardsEMBO Member (2016)
Scientific career
Fields
Institutions
Doctoral advisorVenki Ramakrishnan
Other academic advisorsRon Vale
Websitewww2.mrc-lmb.cam.ac.uk/groups/cartera/

Andrew P. Carter FRS is a British structural biologist who works at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge, UK. He is known for his work on the microtubule motor dynein.

Education

Carter studied Biochemistry at the University of Oxford, graduating in 1999. He obtained a PhD in 2003 from the MRC Laboratory of Molecular Biology where he worked with Venki Ramakrishnan on the ribosome. He was a member of the team in Ramakrishnan's lab that solved the first X-ray crystal structure of the small (30S) ribosomal subunit. Carter also determined structures of 30S bound to antibiotics and bound to the initiation factor IF1. Ramakrishnan shared the Nobel prize in Chemistry for the team's work on the 30S.

Career and research

Carter was a post-doc in Ron Vale's lab at University of California, San Francisco from 2003 to 2010. During his post-doc, he studied the molecular motor protein, dynein using X-ray crystallography and single molecule fluorescence microscopy.

He became a group leader at MRC Laboratory of Molecular Biology in Cambridge in 2010 where he uses X-ray crystallography, electron microscopy, and single molecule microscopy assays to understand how dynein transports cargo. His group solved X-ray crystal structures of the dynein motor domain showing how it generates force to pull cargos along microtubules and reconstituted a recombinant dynein, showing how its processive movement is activated by cofactors/cargo adaptors. His group used cryoEM to solve the structure of dynein's cofactor dynactin and the full length dynein complex. They showed how dynein and dynactin come together in the presence of cargos and how this activates transport.

Grants, awards and honours

References

  1. ^ Schmidt, Helgo; Zalyte, Ruta; Urnavicius, Linas; Carter, Andrew P. (19 February 2015). "Structure of human cytoplasmic dynein-2 primed for its power stroke". Nature. 518 (7539): 435–438. Bibcode:2015Natur.518..435S. doi:10.1038/nature14023. ISSN 1476-4687. PMC 4336856. PMID 25470043.
  2. ^ Urnavicius, Linas; Zhang, Kai; Diamant, Aristides G.; Motz, Carina; Schlager, Max A.; Yu, Minmin; Patel, Nisha A.; Robinson, Carol V.; Carter, Andrew P. (27 March 2015). "The structure of the dynactin complex and its interaction with dynein". Science. 347 (6229): 1441–1446. Bibcode:2015Sci...347.1441U. doi:10.1126/science.aaa4080. ISSN 1095-9203. PMC 4413427. PMID 25814576.
  3. ^ Zhang, Kai; Foster, Helen E.; Rondelet, Arnaud; Lacey, Samuel E.; Bahi-Buisson, Nadia; Bird, Alexander W.; Carter, Andrew P. (15 June 2017). "Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated". Cell. 169 (7): 1303–1314.e18. doi:10.1016/j.cell.2017.05.025. ISSN 1097-4172. PMC 5473941. PMID 28602352.
  4. Urnavicius, Linas; Lau, Clinton K.; Elshenawy, Mohamed M.; Morales-Rios, Edgar; Motz, Carina; Yildiz, Ahmet; Carter, Andrew P. (7 February 2018). "Cryo-EM shows how dynactin recruits two dyneins for faster movement". Nature. 554 (7691): 202–206. Bibcode:2018Natur.554..202U. doi:10.1038/nature25462. ISSN 1476-4687. PMC 5988349. PMID 29420470.
  5. "2012 Alumni Lecture celebrating Oxford Biochemistry graduate success Page - Department of Biochemistry, University of Oxford". www.bioch.ox.ac.uk. Archived from the original on 13 August 2018. Retrieved 26 August 2018.
  6. Wimberly, B. T.; Brodersen, D. E.; Clemons, W. M.; Morgan-Warren, R. J.; Carter, A. P.; Vonrhein, C.; Hartsch, T.; Ramakrishnan, V. (21 September 2000). "Structure of the 30S ribosomal subunit". Nature. 407 (6802): 327–339. Bibcode:2000Natur.407..327W. doi:10.1038/35030006. ISSN 0028-0836. PMID 11014182. S2CID 4419944.
  7. Carter, A. P.; Clemons, W. M.; Brodersen, D. E.; Morgan-Warren, R. J.; Wimberly, B. T.; Ramakrishnan, V. (21 September 2000). "Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics". Nature. 407 (6802): 340–348. Bibcode:2000Natur.407..340C. doi:10.1038/35030019. ISSN 0028-0836. PMID 11014183. S2CID 4408938.
  8. Carter, A. P.; Clemons, W. M.; Brodersen, D. E.; Morgan-Warren, R. J.; Hartsch, T.; Wimberly, B. T.; Ramakrishnan, V. (19 January 2001). "Crystal structure of an initiation factor bound to the 30S ribosomal subunit". Science. 291 (5503): 498–501. Bibcode:2001Sci...291..498C. doi:10.1126/science.1057766. ISSN 0036-8075. PMID 11228145.
  9. "Venkatraman Ramakrishnan - Nobel Lecture: Unraveling the Structure of the Ribosome". NobelPrize.org. Retrieved 26 August 2018.
  10. "Carter". valelab.ucsf.edu. Retrieved 25 August 2018.
  11. Carter, Andrew P.; Garbarino, Joan E.; Wilson-Kubalek, Elizabeth M.; Shipley, Wesley E.; Cho, Carol; Milligan, Ronald A.; Vale, Ronald D.; Gibbons, I. R. (12 December 2008). "Structure and functional role of dynein's microtubule-binding domain". Science. 322 (5908): 1691–1695. Bibcode:2008Sci...322.1691C. doi:10.1126/science.1164424. ISSN 1095-9203. PMC 2663340. PMID 19074350.
  12. Carter, Andrew P.; Cho, Carol; Jin, Lan; Vale, Ronald D. (4 March 2011). "Crystal structure of the dynein motor domain". Science. 331 (6021): 1159–1165. Bibcode:2011Sci...331.1159C. doi:10.1126/science.1202393. ISSN 1095-9203. PMC 3169322. PMID 21330489.
  13. Schlager, Max A.; Hoang, Ha Thi; Urnavicius, Linas; Bullock, Simon L.; Carter, Andrew P. (1 September 2014). "In vitro reconstitution of a highly processive recombinant human dynein complex". The EMBO Journal. 33 (17): 1855–1868. doi:10.15252/embj.201488792. ISSN 1460-2075. PMC 4158905. PMID 24986880.
  14. "LMB Student Prize - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology. Retrieved 26 August 2018.
  15. "Agouron Institute | Fellowships". agi.org. Retrieved 26 August 2018.
  16. Cambridge, Clare College. "Dr Andrew Carter - Clare College Cambridge". www.clare.cam.ac.uk. Retrieved 25 August 2018.
  17. adit. "22 young group leaders recognized as EMBO Young Investigators". EMBO. Retrieved 26 August 2018.
  18. ^ "Investigator Awards in Science: people we've funded | Wellcome". wellcome.ac.uk. Retrieved 26 August 2018.
  19. "Find people in the EMBO Communities". people.embo.org. Retrieved 26 August 2018.
  20. "58 life science researchers elected as new EMBO Members". EMBO. Archived from the original on 15 August 2016. Retrieved 26 August 2018.
  21. "Outstanding scientists elected as Fellows of the Royal Society". Royal Society. Retrieved 18 May 2024.
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