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Anion exchange transporter

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Protein-coding gene in the species Homo sapiens
SLC26A7
Identifiers
AliasesSLC26A7, SUT2, solute carrier family 26 member 7
External IDsOMIM: 608479; MGI: 2384791; HomoloGene: 13770; GeneCards: SLC26A7; OMA:SLC26A7 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)
Chromosome 8 (human)Genomic location for SLC26A7Genomic location for SLC26A7
Band8q21.3Start91,209,494 bp
End91,398,155 bp
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)
Chromosome 4 (mouse)Genomic location for SLC26A7Genomic location for SLC26A7
Band4|4 A1Start14,502,430 bp
End14,621,805 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • thyroid gland

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • retinal pigment epithelium

  • renal medulla

  • human kidney

  • testicle

  • endometrium

  • lymph node

  • placenta
Top expressed in
  • vestibular membrane of cochlear duct

  • retinal pigment epithelium

  • ciliary body

  • iris

  • olfactory epithelium

  • renal corpuscle

  • vestibular sensory epithelium

  • pineal gland

  • lumbar spinal ganglion

  • molar
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

115111

208890

Ensembl

ENSG00000147606

ENSMUSG00000040569

UniProt

Q8TE54

Q8R2Z3

RefSeq (mRNA)

NM_134266
NM_001282356
NM_001282357
NM_052832

NM_145947

RefSeq (protein)

NP_001269285
NP_001269286
NP_439897
NP_599028

NP_666059

Location (UCSC)Chr 8: 91.21 – 91.4 MbChr 4: 14.5 – 14.62 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Splice variants that use both alternate transcription initiation and polyadenylation sites have been described for this gene.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000147606 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040569 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (April 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". The Journal of Biological Chemistry. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
  6. Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (February 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
  7. Xu J, Worrell RT, Li HC, Barone SL, Petrovic S, Amlal H, Soleimani M (April 2006). "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion". Journal of the American Society of Nephrology. 17 (4): 956–67. doi:10.1681/ASN.2005111174. PMC 11627242. PMID 16524946.
  8. ^ "Entrez Gene: SLC26A7 solute carrier family 26, member 7".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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