Apalachicola may refer to:
- Apalachicola band, an association of Native American towns along the Apalachicola River in Florida in the early 19th century
- Apalachicola Province, an association of Native American towns on the Chattahoochee River in Alabama and Georgia that became the Lower Towns of the Muscogee Confederacy
- Apalachicola (tribal town), a Native American town that was the namesake of the Apalachicola Province
Places
- Apalachicola, Florida
- Apalachicola River
- Apalachicola Bay
- Apalachicola National Forest
- Apalachicola Regional Airport
- Port of Apalachicola
Railroad
Ships
- Apalachicola (YTB-767), a tugboat in the United States Navy.
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