Arguello (Spanish pronunciation: [aɾˈɣeʎo]) is a Spanish surname. Notable people with the surname include:
- Casimiro Abdon Irala Arguello (born 1936), known as Padre Irala, Paraguayan-Brazilian Jesuit priest, writer, musician and songwriter
- Christine Arguello (born 1955), American lawyer, jurist and judge
- Irma Arguello, Argentine international security expert
- Marcella Arguello (born 1985), American comedian
- Ricardo Arguello (fl. 1932), Mexican sprinter
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