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Artemotil

Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	not available
Routes of administration	Intramuscular injection
ATC code	P01BE04 (WHO)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	20 hours
Identifiers
IUPAC name (5aS,6R,8aS,9R,10S,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxydioxepinoisochromene
CAS Number	75887-54-6
PubChem CID	3000469
ChemSpider	2272064
UNII	XGL7GFB9YI
ChEMBL	ChEMBL301267
Chemical and physical data
Formula	C17H28O5
Molar mass	312.406 g·mol
3D model (JSmol)	Interactive image
SMILES CCO1(2CC(324(O1)O(CC3)(OO4)C)C)C
InChI InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1 Key:NLYNIRQVMRLPIQ-XQLAAWPRSA-N
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Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.

References

1. "The International Pharmacopoeia - Sixth Edition - Artemotil" (PDF). 2016. Retrieved 10 April 2019.
2. Yeates RA (April 2002). "Artemotil Artecef". Current Opinion in Investigational Drugs. 3 (4). London, England: 545–9. PMID 12090721.

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