Ayerza is an Argentine surname shared by several notable people, among them being:
- Abel Ayerza (1861–1918), Argentine doctor who gave his name to the cardiological condition Ayerza syndrome
- Francisco Ayerza [es] (1860-1901), Argentine photographer
- Hernán Cullen Ayerza [es] (1879-1936), Argentinian sculptor
- Josefina Ayerza (b. before 1970), Argentine writer and psychoanalyst living in the United States
- Marcos Ayerza (b. 1983), Argentine rugby player
- Toribio Ayerza (1815–1884), Argentine physician
See also
- Ayerza syndrome - Medical condition named for Abel Ayerza
- Cotesia ayerza - species of wasp
- Estación Francisco Ayerza [es] - Train station in Argentina
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