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BRK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P8C, 4N78
Identifiers
Aliases	BRK1, C3orf10, MDS027, hHBrk1, HSPC300, BRICK1, SCAR/WAVE actin nucleating complex subunit, BRICK1 subunit of SCAR/WAVE actin nucleating complex
External IDs	OMIM: 611183; MGI: 1915406; HomoloGene: 10210; GeneCards: BRK1; OMA:BRK1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.3 Start 10,115,675 bp End 10,127,190 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 E3 Start 113,581,733 bp End 113,593,912 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm skin of arm islet of Langerhans right testis monocyte tibial arteries left coronary artery right coronary artery left testis smooth muscle tissue Top expressed in medullary collecting duct external carotid artery endocardial cushion saccule internal carotid artery ureter renal corpuscle olfactory tubercle epithelium of lens otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein-containing complex binding identical protein binding Cellular component cytoplasm cytosol extracellular exosome cytoskeleton SCAR complex lamellipodium Biological process vascular endothelial growth factor receptor signaling pathway Rac protein signal transduction positive regulation of Arp2/3 complex-mediated actin nucleation in utero embryonic development positive regulation of lamellipodium assembly actin cytoskeleton organization Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of cell population proliferation protein homotrimerization actin filament organization cell motility regulation of actin polymerization or depolymerization positive regulation of protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55845 101314 Ensembl ENSG00000254999 ENSMUSG00000033940 UniProt Q8WUW1 Q91VR8 RefSeq (mRNA) NM_018462 NM_133937 RefSeq (protein) NP_060932 NP_598698 Location (UCSC) Chr 3: 10.12 – 10.13 Mb Chr 6: 113.58 – 113.59 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

BRICK1 is a putative micropeptide protein that in humans is encoded by the C3orf10 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000254999 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000033940 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maranchie JK, Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, Klausner RD, Linehan WM (Jan 2004). "Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location". Human Mutation. 23 (1): 40–6. doi:10.1002/humu.10302. PMID 14695531. S2CID 20671312.
6. "Entrez Gene: C3orf10 chromosome 3 open reading frame 10".

Further reading

• Cascón A, Escobar B, Montero-Conde C, Rodríguez-Antona C, Ruiz-Llorente S, Osorio A, Mercadillo F, Letón R, Campos JM, García-Sagredo JM, Benítez J, Malumbres M, Robledo M (Jun 2007). "Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients". Human Mutation. 28 (6): 613–21. doi:10.1002/humu.20496. PMID 17311301. S2CID 20428491.
• Mayne M, Moffatt T, Kong H, McLaren PJ, Fowke KR, Becker KG, Namaka M, Schenck A, Bardoni B, Bernstein CN, Melanson M (Apr 2004). "CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion". European Journal of Immunology. 34 (4): 1217–27. doi:10.1002/eji.200324726. PMID 15048733.
• Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. 418 (6899): 790–3. Bibcode:2002Natur.418..790E. doi:10.1038/nature00859. PMID 12181570. S2CID 4350733.
• Witke W, Podtelejnikov AV, Di Nardo A, Sutherland JD, Gurniak CB, Dotti C, Mann M (Feb 1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly". The EMBO Journal. 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMC 1170446. PMID 9463375.
• Kitamura T, Kitamura Y, Yonezawa K, Totty NF, Gout I, Hara K, Waterfield MD, Sakaue M, Ogawa W, Kasuga M (Feb 1996). "Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck". Biochemical and Biophysical Research Communications. 219 (2): 509–14. doi:10.1006/bbrc.1996.0264. hdl:20.500.14094/D1001555. PMID 8605018.

External links

• Human BRK1 genome location and BRK1 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein BRICK1

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