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BRMS1

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Protein-coding gene in the species Homo sapiens
BRMS1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2XUS, 4AUV

Identifiers
AliasesBRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator
External IDsOMIM: 606259; MGI: 2388804; HomoloGene: 32260; GeneCards: BRMS1; OMA:BRMS1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for BRMS1Genomic location for BRMS1
Band11q13.2Start66,337,333 bp
End66,345,125 bp
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)
Chromosome 19 (mouse)Genomic location for BRMS1Genomic location for BRMS1
Band19|19 AStart5,091,382 bp
End5,099,945 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • mucosa of transverse colon

  • monocyte

  • skin of leg

  • skin of abdomen

  • body of stomach

  • body of pancreas

  • sural nerve

  • minor salivary glands

  • mucosa of esophagus
Top expressed in
  • spermatid

  • blastocyst

  • yolk sac

  • morula

  • lip

  • right kidney

  • granulocyte

  • embryo

  • embryo

  • neural layer of retina
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25855

107392

Ensembl

ENSG00000174744

ENSMUSG00000080268

UniProt

Q9HCU9

Q99N20

RefSeq (mRNA)

NM_015399
NM_001024957
NM_001024958

NM_134155
NM_001374047
NM_001374048

RefSeq (protein)

NP_001020128
NP_056214

NP_598916
NP_001360976
NP_001360977

Location (UCSC)Chr 11: 66.34 – 66.35 MbChr 19: 5.09 – 5.1 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000174744Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000080268Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research. 60 (11): 2764–9. PMID 10850410.
  6. ^ "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
  7. Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

External links

Further reading


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