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BW-501C67

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Peripheral serotonin antagonist

Pharmaceutical compound
BW-501C67
Clinical data
Other namesBW-501; BW-501C; α-Anilino-N-2-(3-chlorophenoxy)-propylacetamidine
Drug classPeripherally selective serotonin receptor antagonist
Identifiers
IUPAC name
  • 2-anilino-N'-ethanimidamide
PubChem CID
ChemSpider
Chemical and physical data
FormulaC17H20ClN3O
Molar mass317.82 g·mol
3D model (JSmol)
SMILES
  • C1=CC=C(C=C1)NCC(=NCCCOC2=CC=CC=C2Cl)N
InChI
  • InChI=1S/C17H20ClN3O/c18-15-9-4-5-10-16(15)22-12-6-11-20-17(19)13-21-14-7-2-1-3-8-14/h1-5,7-10,21H,6,11-13H2,(H2,19,20)
  • Key:IKCBXYTYVXLXIR-UHFFFAOYSA-N

BW-501C67 is a peripherally selective serotonin 5-HT2A and 5-HT2C receptor antagonist which is used in scientific research. It shows selectivity for the serotonin 5-HT2 receptors over the α1-adrenergic receptor.

The drug antagonizes peripheral but not central effects of serotonin receptor agonists like serotonin. As examples, it has been found to antagonize the sympathomimetic effects of serotonin in animals, including vasoconstriction and pressor effects, but does not block centrally mediated effects like increased corticosterone secretion or myoclonus.

BW-501C67 and analogues were patented for use in combination with serotonin 5-HT2A receptor agonists like serotonergic psychedelics in 2023.

See also

References

  1. ^ Middlemiss DN, Hibert M, Fozard JR (1986). "Chapter 5. Drugs Acting at Central 5-Hydroxytryptamine Receptors". Annual Reports in Medicinal Chemistry. Vol. 21. Elsevier. pp. 41–50. doi:10.1016/s0065-7743(08)61115-x. ISBN 978-0-12-040521-3.
  2. ^ Sharp T, Boothman L, Raley J, Quérée P (December 2007). "Important messages in the 'post': recent discoveries in 5-HT neurone feedback control". Trends in Pharmacological Sciences. 28 (12): 629–636. doi:10.1016/j.tips.2007.10.009. PMID 17996955.
  3. ^ Green AR (December 1984). "5-HT-mediated behavior. Animal studies". Neuropharmacology. 23 (12B): 1521–1528. doi:10.1016/0028-3908(84)90096-0. PMID 6152026.
  4. Ramage AG (November 2001). "Central cardiovascular regulation and 5-hydroxytryptamine receptors". Brain Research Bulletin. 56 (5): 425–439. doi:10.1016/s0361-9230(01)00612-8. PMID 11750788.
  5. Chaouloff F, Layeillon C, Baudrie V (January 1993). "5-HT1C/5-HT2 receptor blockade prevents 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane-, but not stress-induced increases in brain tryptophan". European Journal of Pharmacology. 231 (1): 77–82. doi:10.1016/0014-2999(93)90686-c. PMID 8095238.
  6. ^ Fuller RW, Kurz KD, Mason NR, Cohen ML (June 1986). "Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67". European Journal of Pharmacology. 125 (1): 71–77. doi:10.1016/0014-2999(86)90084-1. PMID 3732393.
  7. ^ Cook DA (1984). "The pharmacology of cerebral vasospasm". Pharmacology. 29 (1): 1–16. doi:10.1159/000137986. PMID 6379682.
  8. Fuller RW (1996). "Serotonin receptors involved in regulation of pituitary-adrenocortical function in rats". Behavioural Brain Research. 73 (1–2): 215–219. doi:10.1016/0166-4328(96)00099-x. PMID 8788505.
  9. WO 2023028086, Kruegel AC, "Combinations of peripheral 5-HT2A receptor antagonists and central 5-HT2A receptor agonists", published 2 March 2023, assigned to Gilgamesh Pharmaceuticals, Inc. 
Serotonin receptor modulators
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7


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