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BW284C51

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BW284C51
Names

Preferred IUPAC name 4,4′-(3-Oxopentane-1,5-diyl)bis dibromide
Identifiers
CAS Number	402-40-4
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL464538
ChemSpider	9437
ECHA InfoCard	100.129.545
PubChem CID	9820
CompTox Dashboard (EPA)	DTXSID90960624
InChI InChI=1S/C27H38N2O.2BrH/c1-7-21-28(3,4)25-15-9-23(10-16-25)13-19-27(30)20-14-24-11-17-26(18-12-24)29(5,6)22-8-2;;/h7-12,15-18H,1-2,13-14,19-22H2,3-6H3;2*1H/q+2;;/p-2Key: WKDURMTZOWGWTD-UHFFFAOYSA-L
SMILES C(C)(CC=C)c1ccc(cc1)CCC(=O)CCc2ccc(cc2)(C)(C)CC=C..
Properties
Chemical formula	C₂₇H₃₈Br₂N₂O
Molar mass	566.422 g·mol
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Toxic
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H300, H310, H330
Precautionary statements	P260, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P304+P340, P310, P320, P321, P322, P330, P361, P363, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references

Chemical compound

BW284C51 is a selective acetylcholinesterase inhibitor. It is also a nicotinic antagonist.

See also

References

FULTON, MP; MOGEY, GA (June 1954). "Some selective inhibitors of true cholinesterase". British Journal of Pharmacology and Chemotherapy. 9 (2): 138–44. doi:10.1111/j.1476-5381.1954.tb00832.x. PMC 1509427. PMID 13172421.
Olivera-Bravo, S; Ivorra, I; Morales, A (January 2005). "The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane". British Journal of Pharmacology. 144 (1): 88–97. doi:10.1038/sj.bjp.0705965. PMC 1575971. PMID 15644872.

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Acetylcholine metabolism and transport modulators

Enzyme
(modulators)

ChATTooltip Choline acetyltransferase

AChETooltip Acetylcholinesterase

BChETooltip Butyrylcholinesterase

Inhibitors: Affinine
Affinisine
Conodurine
Cymserine
Ladostigil
Profenamine (ethopropazine)
Rivastigmine
Tacrine
ZINC-12613047
Many of the other AChE inhibitors listed above

Transporter
(modulators)

CHTTooltip Choline transporter

Inhibitors: Hemicholinium-3 (hemicholine)
Triethylcholine

Enhancers: Coluracetam

VAChTTooltip Vesicular acetylcholine transporter

Inhibitors: Vesamicol

Release
(modulators)

SNAP-25Tooltip Synaptosomal-associated protein 25 inactivators: Botulinum toxin (A, C, E)

VAMPTooltip Vesicle-associated membrane protein inactivators: Botulinum toxin (B, D, F, G)

Others: Bungarotoxins (β-bungarotoxin, γ-bungarotoxin)

LPHNTooltip Latrophilin agonists: α-Latrotoxin

Others: Atracotoxins (e.g., robustoxin, versutoxin)
Crotoxin

See also: Receptor/signaling modulators; Muscarinic acetylcholine receptor modulators; Nicotinic acetylcholine receptor modulators

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Nicotinic acetylcholine receptor modulators

nAChRsTooltip Nicotinic acetylcholine receptors

Agonists
(and PAMsTooltip positive allosteric modulators)

Antagonists
(and NAMsTooltip negative allosteric modulators)

Precursors
(and prodrugs)

See also: Receptor/signaling modulators; Muscarinic acetylcholine receptor modulators; Acetylcholine metabolism/transport modulators

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