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BZW1
Identifiers
Aliases	BZW1, BZAP45, Nbla10236, basic leucine zipper and W2 domains 1, 5MP2
External IDs	MGI: 1914132; HomoloGene: 41651; GeneCards: BZW1; OMA:BZW1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.1 Start 200,810,594 bp End 200,827,338 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C1.3 Start 58,432,057 bp End 58,446,512 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva amniotic fluid germinal epithelium Epithelium of choroid plexus gingival epithelium parietal pleura mucosa of paranasal sinus stromal cell of endometrium cartilage tissue epithelium of nasopharynx Top expressed in endothelial cell of lymphatic vessel renal corpuscle somite abdominal wall primitive streak maxillary prominence mandibular prominence ventricular zone endocardial cushion condyle More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding cadherin binding Cellular component cytoplasm membrane Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9689 66882 Ensembl ENSG00000082153 ENSMUSG00000051223 UniProt Q7L1Q6 Q9CQC6 RefSeq (mRNA) NM_001207067 NM_001207068 NM_001207069 NM_014670 NM_001321688 NM_001321690 NM_001321691 NM_001321693 NM_001321694 NM_025824 RefSeq (protein) NP_001193996 NP_001193997 NP_001193998 NP_001308617 NP_001308619 NP_001308620 NP_001308622 NP_001308623 NP_055485 NP_080100 Location (UCSC) Chr 2: 200.81 – 200.83 Mb Chr 1: 58.43 – 58.45 Mb PubMed search
Wikidata
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Basic leucine zipper and W2 domain-containing protein 1 is a protein that in humans is encoded by the BZW1 gene and expressed in the nucleus. It enables RNA and cadherin binding activity.

Salivary gland carcinoma and eastern equine encephalitis are associated with BZW1.

Interactions

BZW1 has been shown to interact with PSTPIP1 and CDC5L.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000082153 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000051223 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (September 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
6. Mitra P, Vaughan PS, Stein JL, Stein GS, van Wijnen AJ (August 2001). "Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription". Biochemistry. 40 (35): 10693–9. doi:10.1021/bi010529o. PMID 11524015.
7. "Entrez Gene: BZW1 basic leucine zipper and W2 domains 1".
8. "BZW1 basic leucine zipper and W2 domains 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-10-20.
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
10. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.

External links

• Human BZW1 genome location and BZW1 gene details page in the UCSC Genome Browser.

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