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Bacillolysin (EC 3.4.24.28, Bacillus metalloendopeptidase, Bacillus subtilis neutral proteinase, anilozyme P 10, Bacillus metalloproteinase, Bacillus neutral proteinase, megateriopeptidase) is an enzyme. This enzyme catalyses the following chemical reaction

Similar, but not identical, to that of thermolysin

This enzyme is present in many Bacillus species, including B. subtilis, B. amyloliquefaciens, B. megaterium, B. mesentericus, B. cereus and B. stearothermophilus.

References

1. Morihara K, Tsuzuki H, Oka T (March 1968). "Comparison of the specificities of various neutral proteinases from microorganisms". Archives of Biochemistry and Biophysics. 123 (3): 572–88. doi:10.1016/0003-9861(68)90179-3. PMID 4967801.
2. Millet J, Acher R (July 1969). "[Specificity of megateriopeptidase: an amino-endopeptidase with hydrophobic characteristics]". European Journal of Biochemistry. 9 (4): 456–62. doi:10.1111/j.1432-1033.1969.tb00631.x. PMID 4980359.
3. Feder J, Keay L, Garrett LR, Cirulis N, Moseley MH, Wildi BS (October 1971). "Bacillus cereus neutral protease". Biochimica et Biophysica Acta (BBA) - Protein Structure. 251 (1): 74–8. doi:10.1016/0005-2795(71)90061-4. PMID 5002444.
4. Holmquist B, Vallee BL (January 1976). "Esterase activity of zinc neutral proteases". Biochemistry. 15 (1): 101–7. doi:10.1021/bi00646a016. PMID 2276.
5. Vasantha N, Thompson LD, Rhodes C, Banner C, Nagle J, Filpula D (September 1984). "Genes for alkaline protease and neutral protease from Bacillus amyloliquefaciens contain a large open reading frame between the regions coding for signal sequence and mature protein". Journal of Bacteriology. 159 (3): 811–9. doi:10.1128/JB.159.3.811-819.1984. PMC 215730. PMID 6090391.
6. Yang MY, Ferrari E, Henner DJ (October 1984). "Cloning of the neutral protease gene of Bacillus subtilis and the use of the cloned gene to create an in vitro-derived deletion mutation". Journal of Bacteriology. 160 (1): 15–21. doi:10.1128/JB.160.1.15-21.1984. PMC 214674. PMID 6090407.
7. Takagi M, Imanaka T, Aiba S (September 1985). "Nucleotide sequence and promoter region for the neutral protease gene from Bacillus stearothermophilus". Journal of Bacteriology. 163 (3): 824–31. doi:10.1128/JB.163.3.824-831.1985. PMC 219205. PMID 2993245.
8. Sidler W, Niederer E, Suter F, Zuber H (July 1986). "The primary structure of Bacillus cereus neutral proteinase and comparison with thermolysin and Bacillus subtilis neutral proteinase". Biological Chemistry Hoppe-Seyler. 367 (7): 643–57. doi:10.1515/bchm3.1986.367.2.643. PMID 3092843.
9. Pauptit RA, Karlsson R, Picot D, Jenkins JA, Niklaus-Reimer AS, Jansonius JN (February 1988). "Crystal structure of neutral protease from Bacillus cereus refined at 3.0 A resolution and comparison with the homologous but more thermostable enzyme thermolysin". Journal of Molecular Biology. 199 (3): 525–37. doi:10.1016/0022-2836(88)90623-7. PMID 3127592.
10. Stoeva S, Kleinschmidt T, Mesrob B, Braunitzer G (January 1990). "Primary structure of a zinc protease from Bacillus mesentericus strain 76". Biochemistry. 29 (2): 527–34. doi:10.1021/bi00454a029. PMID 2302386.

External links

• Bacillolysin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 3.4.24