Back in Business may refer to:
- Back in Business (1997 film), an action film starring Brian Bosworth
- Back in Business (EPMD album), 1997
- Back in Business (Eartha Kitt album), 1994
- "Back in Business", a song by AC/DC from their 1985 album Fly on the Wall
- Back in Business (Desperate Housewives), an episode of the TV series Desperate Housewives
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