Balestrini is an Italian surname. Notable people with the surname include:
- Alberto Balestrini (born 1931), Argentine fencer
- Alberto Balestrini (1947–2017), Argentine politician
- Carlo Balestrini (1868–1922), Italian painter
- Carlos Balestrini (1880–1972), Argentine sport shooter
- Giulio Balestrini (1907–?), Italian footballer
- Nanni Balestrini (1935–2019), Italian poet
- Roberto Balestrini (born 1962), FootGolf pioneer. Top 10 most innovative people in golf (Golf Inc, Magazine - 2015).
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