Battle, fall, siege or sack of Ctesiphon may refer to:
- Battle of Ctesiphon (116), under Roman Emperor Trajan
- Battle of Ctesiphon (165), under Lucius Verus
- Battle of Ctesiphon (198), under Septimius Severus
- Battle of Ctesiphon (263), under Odaenathus
- Battle of Ctesiphon (283), under Carus
- Battle of Ctesiphon (298), under Galerius
- Battle of Ctesiphon (363), between Roman emperor Julian the Apostate & Persian emperor Shapur II outside the walls of Ctesiphon
- Siege of Ctesiphon (629), between the forces of Shahrbaraz and Ardashir III, successful
- Siege of Ctesiphon (637), the Arabian Rashidun army captures the Sasanian capital
- Battle of Ctesiphon (1915), between the British and Ottoman empires
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