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Bernhard Brenner

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Bernhard Brenner is a scientist who, through his experiments, elucidated the repeated cycles of stretch and release of muscle fibers under isometric conditions. Because of this, these cycles were named as "Brenner Cycles".

Biography

Brenner was born in Stuttgart, capital of Baden-Württenberg state in Germany. He studied Medicine at the University of Tübingen between the years of 1969-1975. In 1980, Bernhard Brenner became associate researcher visitor at National Institute of Health (NIH) where he clarified that, when the muscle is in its relaxed state, the complex tropomyosin-troponin does not block cross-bridge bounds to actin. Due to this revelation, the pathway of muscle contraction was decoded, and then he correlated a rate of force for muscle redevelopment under calcium regulation called KTR to the number of cross-bridges turnover kinetics. Until 1985, Bernhard Brenner worked with other colleagues Richard Podolsky, Evan Eisenberg, Joseph Chalovich, Lois Greene, Mark Schoenberg, and Leepo Yu, and after this period, Bernhard Brenner returned to Germany and became professor and director of the Institute for Molecular and Cell Physiology at Hannover Medical School (MHH). Later in his career, he started to study mutations in cardiac myosin related to hypertrophic cardiomyopathy. He died in 2017, from cancer.

References

  1. Yu, L.C.; Brenner, B. (March 1989). "Structures of actomyosin crossbridges in relaxed and rigor muscle fibers". Biophysical Journal. 55 (3): 441–453. Bibcode:1989BpJ....55..441Y. doi:10.1016/S0006-3495(89)82838-3. PMC 1330498. PMID 2930830.
  2. Kraft, T.; Chalovich, J.M.; Yu, L.C.; Brenner, B. (June 1995). "Parallel inhibition of active force and relaxed fiber stiffness by caldesmon fragments at physiological ionic strength and temperature conditions: additional evidence that weak cross-bridge binding to actin is an essential intermediate for force generation". Biophysical Journal. 68 (6): 2404–2418. Bibcode:1995BpJ....68.2404K. doi:10.1016/S0006-3495(95)80423-6. PMC 1282151. PMID 7647245.
  3. Kraft Theresia; Montag Judith; Radocaj Ante; Brenner Bernhard (2016-10-14). "Hypertrophic Cardiomyopathy". Circulation Research. 119 (9): 992–995. doi:10.1161/CIRCRESAHA.116.309804. PMID 27737944.
  4. Chalovich, Joseph M.; Kraft, Theresia; Yu, Leepo C. (2017-08-01). "Obituary Bernhard Brenner". Journal of Muscle Research and Cell Motility. 38 (3): 269–270. doi:10.1007/s10974-017-9488-2. ISSN 1573-2657. PMID 29147874. S2CID 2766175.


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