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The Big Central Soccer Conference was a Division Isoccer conference in the NCAA. It was originally known as the Big Central Six Soccer Conference. The founding members were Southern Illinois University Edwardsville (SIU Edwardsville or SIUE), Quincy College (now Quincy University), Marquette University, Northern Illinois University, and the University of Wisconsin-Milwaukee (now athletically branded as "Milwaukee"), with the University of Cincinnati joining in 1988.
Three of the founding members—Quincy, SIU Edwardsville, and Wisconsin–Milwaukee—were Division II schools that played Division I men's soccer (Milwaukee moved to Division I for all sports in 1990, and SIUE did the same in 2008). The conference existed from 1987 through 1990 with nine member schools in its short history. In 1991, the primary conferences of all but the two remaining Division II schools, SIU Edwardsville and Quincy, sponsored competition in men's soccer. Since only the two Division II schools had a need for the Big Central, the conference ceased to exist, and those two, Quincy and SIUE, joined the division II Great Lakes Valley Conference in all sports following a brief period as independents and two seasons in the Mid-Continent Conference.