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In medicinal chemistry and pharmacology, a binding coefficient is a quantity representing the extent to which a chemical compound will bind to a macromolecule. The preferential binding coefficient can be derived from the Kirkwood-Buff solution theory of solutions. Preferential binding is defined as a thermodynamic expression that describes the binding of the cosolvent over the solvent. This is in a system that is open to both the solvent and cosolvent. Consequently, preferential interaction coefficients are measures of interactions that involve “solutes that participate in a reaction in solution.”

See also

• Binding constant
• Partition coefficient
• Binding affinity

References

1. Schurr JM, Rangel DP, Aragon SR. (2005) "A Contribution to the Theory of Preferential Interaction Coefficients." Archived October 11, 2007, at the Wayback Machine Biophysical Journal. 89:2258-2276.
2. Shulgin IL, Ruckenstein E (2006) "A Protein Molecule in a Mixed Solvent: The Preferential Binding Parameter via the Kirkwood-Buff theory." Biophysical Journal. 90:704–707.
3. Pierce V, Kang M, Weerasinghe S, Smith PE. (2008) "Recent Applications of Kirkwood-Buff Theory to Biological Systems." Cell Biochem Biophys. 50(1):1-22.
4. Thomas Record Jr. M, Anderson CF. (1995) "Interpretation of Preferential Interaction Coefficients of Nonelectrolytes and of Electrolyte Ions in Terms of a Two-Domain Model." Biophysical Journal. 68:786-794.

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