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Bioelectrospray

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Bio-electrospraying is a technology that enables the deposition of living cells on various targets with a resolution that depends on cell size and not on the jetting phenomenon. It is envisioned that "unhealthy cells would draw a different charge at the needle from healthy ones, and could be identified by the mass spectrometer", with tremendous implications in the health care industry.

The early versions of bio-electrosprays were employed in several areas of research, most notably self-assembly of carbon nanotubes. Although the self-assembly mechanism is not clear yet, "elucidating electrosprays as a competing nanofabrication route for forming self-assemblies with a wide range of nanomaterials in the nanoscale for top-down based bottom-up assembly of structures." Future research may reveal important interactions between migrating cells and self-assembled nanostructures. Such nano-assemblies formed by means of this top-down approach could be explored as a bottom-up methodology for encouraging cell migration to those architectures for forming cell patterns to nano-electronics, which are a few examples, respectively.

After initial exploration with a single protein, increasingly complex systems were studied by bio-electrosprays. These include, but are not limited to, neuronal cells, stem cells, and even whole embryos. The potential of the method was demonstrated by investigating cytogenetic and physiological changes of human lymphocyte cells as well as conducting comprehensive genetic, genomic and physiological state studies of human cells and cells of the model yeast Saccharomyces cerevisiae.

See also

References

  1. Suwan N Jayasinghe (2007). "Direct cell engineering reaches the jet age". Materials Today. 10 (6): 60. doi:10.1016/S1369-7021(07)70159-1.
  2. Suwan N Jayasinghe (2006). "An advanced jet-based approach to processing nanotubes". Physica E. 31 (1): 17–26. doi:10.1016/j.physe.2005.08.013.
  3. Suwan N Jayasinghe (2006). "A novel technique for forming self-assembled nanotube structures". Fullerenes, Nanotubes, and Carbon Nanostructures. 14 (1): 67–81. doi:10.1080/15363830500538524. S2CID 136903955.
  4. Suwan N Jayasinghe (2006). "Self-assembled nanostructures via electrospraying". Physica E. 33 (2): 398–406. doi:10.1016/j.physe.2006.04.011.
  5. Suwan N Jayasinghe (2008). "Electrospray self-assembly: An emerging jet-based route for directly forming nanoscaled structures". Physica E. 40 (9): 2911–2915. doi:10.1016/j.physe.2008.02.005.
  6. R Pareta; A Brindley; MJ Edirisinghe; SN Jayasinghe; ZB Luklinska (2005). "Electrohydrodynamic atomization of protein (bovine serum albumin)". Journal of Materials Science: Materials in Medicine. 16 (10): 919–925. doi:10.1007/s10856-005-4426-z. PMID 16167100. S2CID 42213925.
  7. Peter AM Eagles; Amer N Quresh; Suwan N. Jayasinghe (2006). "Electrohydrodynamic jetting of mouse neuronal cells". Biochemical Journal. 394 (2): 375–378. doi:10.1042/BJ20051838. PMC 1408668. PMID 16393140.
  8. Napachanok Mongkoldhumrongkul; James M Flanagan; Suwan N Jayasinghe (2009). "Direct jetting approaches for handling stem cells". Biomedical Materials. 4 (1): 015018. doi:10.1088/1748-6041/4/1/015018. PMID 19193972. S2CID 22508896.
  9. Anil Abeyewickreme; Albert Kwok; Jean R. McEwan; Suwan N. Jayasinghe (2009). "Bio-electrospraying embryonic stem cells: interrogating cellular viability and pluripotency". Biomedical Materials. 4 (1): 015018. doi:10.1088/1748-6041/4/1/015018. PMID 19193972. S2CID 22508896.
  10. Jonathan DW Clarke; Suwan N Jayasinghe (2008). "Bio-electrosprayed multicellular zebrafish embryos are viable and develop normally". Biomedical Materials. 3 (1): 011001. doi:10.1088/1748-6041/3/1/011001. PMID 18458487. S2CID 3365967.
  11. Timothy J. Geach; Napachanok Mongkoldhumrongkul; Lyle B. Zimmerman; Suwan N Jayasinghe (2009). "Bio-electrospraying living Xenopus tropicalis embryos: investigating the structural, functional and biological integrity of a model organism". Analyst. 134 (4): 743–747. doi:10.1039/b817827e. PMID 19305925.
  12. Helena Kempski; Nicola Austin; Amy Roe; Steve Chatters; Suwan N Jayasinghe (2008). "Pilot study to investigate the possibility of cytogenetic and physiological changes in bio-electrosprayed human lymphocyte cells". Regenerative Medicine. 3 (3): 343–349. doi:10.2217/17460751.3.3.343. PMID 18462057.
  13. Richard P. Hall; Caroline M. Ogilvie; Emma Aarons; Suwan N. Jayasinghe (2008). "Genetic, genomic and physiological state studies on single-needle bio-electrosprayed human cells". Analyst. 133 (10): 1347–1351. doi:10.1039/b806901h. PMID 18810280.
  14. Duncan Greig; Suwan N Jayasinghe (2008). "Genomic, genetic and physiological effects of bio-electrospraying on live cells of the model yeast Saccharomyces cerevisiae". Biomedical Materials. 3 (3): 034125. doi:10.1088/1748-6041/3/3/034125. PMID 18765897. S2CID 5346587.
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