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Bis-gamma-glutamylcystine reductase

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(Redirected from Bis-g-glutamylcystine reductase) Class of enzymes
bis-gamma-glutamylcystine reductase
Identifiers
EC no.1.8.1.13
CAS no.117056-54-9
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Bis-gamma-glutamylcystine reductase (EC 1.8.1.13) is an enzyme that catalyzes the chemical reaction

2 gamma-glutamylcysteine + NADP {\displaystyle \rightleftharpoons } bis-gamma-glutamylcystine + NADPH + H

Thus, the two substrates of this enzyme are gamma-glutamylcysteine and nicotinamide adenine dinucleotide phosphate ion, whereas its 3 products are bis-gamma-glutamylcystine, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is gamma-glutamylcysteine:NADP+ oxidoreductase. This enzyme is also called NADPH2:bis-gamma-glutamylcysteine oxidoreductase. This enzyme participates in glutathione metabolism.

References

Oxidoreductases: sulfur oxidoreductases (EC 1.8)
1.8.1: NAD or NADP
1.8.2: cytochrome
1.8.3: oxygen
1.8.4: disulfide
1.8.5: quinone
1.8.98: Other, known
1.8.99: Other
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